Fields »
ABOUT
HELP
BLOG
TCEB3

GENERAL INFORMATION

Gene name

 TCEB3

Gene description

 Transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A)

Protein class

 Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear and nucleolar expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA005910
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA005910

GENE INFORMATION

Gene name

 TCEB3 (HGNC Symbol)

Synonyms

 SIII, TCEB3A

Description

 Transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A) (HGNC Symbol)

Entrez gene summary

 This gene encodes the protein elongin A, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p36.11

Chromosome location (bp)

 23743155 - 23762059

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000011007 (version 83.38)

Entrez gene

 6924

UniProt

 Q14241 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14241

Antibodypedia

 TCEB3 antibodies

PROTEIN BROWSER
TCEB3-001
TCEB3-003
TCEB3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
TCEB3-001
ENSP00000395574
ENST00000418390
Q14241 [Direct mapping]
Transcription elongation factor B polypeptide 3
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0010467 [gene expression]
GO:0016021 [integral component of membrane]
GO:0016032 [viral process]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0050434 [positive regulation of viral transcription]
GO:0070449 [elongin complex]
Show all
 798 aa
89.9 kDa 		No 0
TCEB3-003
ENSP00000476781
ENST00000609199
A0A024RAC6 [Direct mapping]
Transcription elongation factor B (SIII), polypeptide 3 (110kDa, elongin A), isoform CRA_a; Transcription elongation factor B polypeptide 3
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0003746 [translation elongation factor activity]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0006414 [translational elongation]
GO:0016021 [integral component of membrane]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0070449 [elongin complex]
Show all
 772 aa
87.2 kDa 		No 0
TCEB3-201
ENSP00000484196
ENST00000613537
Q14241 [Direct mapping]
Transcription elongation factor B polypeptide 3
Show all
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003677 [DNA binding]
GO:0004842 [ubiquitin-protein transferase activity]
GO:0005515 [protein binding]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006368 [transcription elongation from RNA polymerase II promoter]
GO:0010467 [gene expression]
GO:0016021 [integral component of membrane]
GO:0016032 [viral process]
GO:0042787 [protein ubiquitination involved in ubiquitin-dependent protein catabolic process]
GO:0050434 [positive regulation of viral transcription]
GO:0070449 [elongin complex]
Show all
 798 aa
89.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.