Cell atlas - CLCN6 - The Human Protein Atlas

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CLCN6

TISSUE

CELL

PATHOLOGY

CELL ATLAS RNA EXPRESSION HUMAN CELLS

GENE/PROTEIN

Antibody validation

Dictionary
	Cytosol
	Plasma membrane

Human cell
	Cytosol
	Plasma Membrane

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GENERAL INFORMATION
Gene name	CLCN6
Gene description	Chloride channel, voltage-sensitive 6
Protein class	Plasma proteins Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION
Summary	Localized to the plasma membrane & cytosol.
RNA cell category	Expressed in all
Protein evidence	Evidence at protein level
Main location	Localized to the Plasma membrane (approved), Cytosol (approved)
Single-cell variation	Single-cell variation in protein expression observed.

DATA RELIABILITY
Reliability score	Approved based on 1 antibody. HPA032097
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ASSAYS

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all Organ Origin Category Expression Alphabetical Cell lines sorted after organ of phenotypic resemblance. Cell lines sorted after biological source for establishment. Cell lines sorted after the cell line category according to Cellosaurus. Cell lines sorted on descending RNA expression. Cell lines sorted alphabetically.

HUMAN CELLS

Summary

Localized to the plasma membrane & cytosol.

Main location

Plasma membrane (approved), Cytosol (approved)


	Toggle channels	Low High G1 S G2 M N/A

Thumbnail	Antibody	Cell line	Location	Single-cell variation	Cell cycle dependent variation
	HPA032097	A-431	Plasma membrane	Intensity
	HPA032097	A-431	Cytosol	Intensity
	HPA032097	U-2 OS	Plasma membrane	Intensity
	HPA032097	U-2 OS	Cytosol	Intensity
	HPA032097	U-251 MG	Plasma membrane	Intensity
	HPA032097	U-251 MG	Cytosol	Intensity

GENE INFORMATION
Gene name	CLCN6 (HGNC Symbol)
Synonyms	CLC-6, KIAA0046
Description	Chloride channel, voltage-sensitive 6 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the voltage-dependent chloride channel protein family. Members of this family can function as either chloride channels or antiporters. This protein is primarily localized to late endosomes and functions as a chloride/proton antiporter. Alternate splicing results in both coding and non-coding variants. Additional alternately spliced variants have been described but their full-length structure is unknown. [provided by RefSeq, Mar 2012]
Chromosome	1
Cytoband	p36.22
Chromosome location (bp)	11806096 - 11843144
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000011021 (version 83.38)
Entrez gene	1185
UniProt	P51797 (UniProt - Evidence at protein level)
neXtProt	NX_P51797
Antibodypedia	CLCN6 antibodies

PROTEIN BROWSER

CLCN6-001	CLCN6-005	CLCN6-006	CLCN6-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLCN6-001 ENSP00000234488 ENST00000346436	P51797 [Direct mapping] Chloride transport protein 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005247 [voltage-gated chloride channel activity] GO:0005524 [ATP binding] GO:0005765 [lysosomal membrane] GO:0006821 [chloride transport] GO:0006884 [cell volume homeostasis] GO:0007165 [signal transduction] GO:0009612 [response to mechanical stimulus] GO:0010008 [endosome membrane] GO:0015297 [antiporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] GO:1903959 [regulation of anion transmembrane transport] Show all	869 aa 97.3 kDa	No	>9
CLCN6-005 ENSP00000365679 ENST00000376496	P51797 [Direct mapping] Chloride transport protein 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005247 [voltage-gated chloride channel activity] GO:0005524 [ATP binding] GO:0005765 [lysosomal membrane] GO:0006821 [chloride transport] GO:0006884 [cell volume homeostasis] GO:0007165 [signal transduction] GO:0010008 [endosome membrane] GO:0015297 [antiporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] GO:1903959 [regulation of anion transmembrane transport] Show all	953 aa 106.4 kDa	No	>9
CLCN6-006 ENSP00000365680 ENST00000376497	Q5SNW4 [Direct mapping] Chloride transport protein 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005247 [voltage-gated chloride channel activity] GO:0006821 [chloride transport] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:1903959 [regulation of anion transmembrane transport] Show all	122 aa 14.2 kDa	No	1
CLCN6-201 ENSP00000308367 ENST00000312413	P51797 [Direct mapping] Chloride transport protein 6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005216 [ion channel activity] GO:0005247 [voltage-gated chloride channel activity] GO:0005524 [ATP binding] GO:0005765 [lysosomal membrane] GO:0006821 [chloride transport] GO:0006884 [cell volume homeostasis] GO:0007165 [signal transduction] GO:0010008 [endosome membrane] GO:0015297 [antiporter activity] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0034220 [ion transmembrane transport] GO:0055085 [transmembrane transport] GO:1903959 [regulation of anion transmembrane transport] Show all	847 aa 94.7 kDa	No	>9

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.