Fields »
ABOUT
HELP
BLOG
MRC2

GENERAL INFORMATION

Gene name

 MRC2

Gene description

 Mannose receptor, C type 2

Protein class

 CD markers
Predicted intracellular proteins
Predicted membrane proteins

Predicted localization

 Intracellular,Membrane

Number of transcripts

 3
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Cytoplasmic expression at variable levels in all tissues.

DATA RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Supported based on 1 antibody.
HPA041991
SHOW MORE

RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Spleen

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 MRC2 (HGNC Symbol)

Synonyms

 CD280, CLEC13E, ENDO180, KIAA0709

Description

 Mannose receptor, C type 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the mannose receptor family of proteins that contain a fibronectin type II domain and multiple C-type lectin-like domains. The encoded protein plays a role in extracellular matrix remodeling by mediating the internalization and lysosomal degradation of collagen ligands. Expression of this gene may play a role in the tumorigenesis and metastasis of several malignancies including breast cancer, gliomas and metastatic bone disease. [provided by RefSeq, Feb 2012]

Chromosome

 17

Cytoband

 q23.2

Chromosome location (bp)

 62627401 - 62693597

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000011028 (version 83.38)

Entrez gene

 9902

UniProt

 Q9UBG0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9UBG0

Antibodypedia

 MRC2 antibodies

PROTEIN BROWSER
MRC2-001
MRC2-004
MRC2-005

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
MRC2-001
ENSP00000307513
ENST00000303375
Q9UBG0 [Direct mapping]
C-type mannose receptor 2
Show all
CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001649 [osteoblast differentiation]
GO:0005515 [protein binding]
GO:0005518 [collagen binding]
GO:0005925 [focal adhesion]
GO:0006897 [endocytosis]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0030246 [carbohydrate binding]
GO:0030574 [collagen catabolic process]
Show all
 1479 aa
166.7 kDa 		Yes 1
MRC2-004
ENSP00000400445
ENST00000446119
E7EME3 [Direct mapping]
C-type mannose receptor 2
Show all
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0016021 [integral component of membrane]
Show all
 345 aa
37.6 kDa 		Yes 1
MRC2-005
ENSP00000463968
ENST00000579432
J3QQZ6 [Direct mapping]
C-type mannose receptor 2
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
 35 aa
4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.