Expression of SLC6A7 in cancer - Summary - The Human Protein Atlas

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SLC6A7

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SLC6A7
Gene description	Solute carrier family 6 (neurotransmitter transporter), member 7
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (colorectal cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enhanced (cerebral cortex, rectum)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA028907
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (colorectal cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA028907

GENE INFORMATION
Gene name	SLC6A7 (HGNC Symbol)
Synonyms	PROT
Description	Solute carrier family 6 (neurotransmitter transporter), member 7 (HGNC Symbol)
Entrez gene summary	This gene is a member of the gamma-aminobutyric acid (GABA) neurotransmitter gene family and encodes a high-affinity mammalian brain L-proline transporter protein. This transporter protein differs from other sodium-dependent plasma membrane carriers by its pharmacological specificity, kinetic properties, and ionic requirements. [provided by RefSeq, Jul 2008]
Chromosome	5
Cytoband	q32
Chromosome location (bp)	150189957 - 150222788
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000011083 (version 83.38)
Entrez gene	6534
UniProt	Q99884 (UniProt - Evidence at transcript level)
neXtProt	NX_Q99884
Antibodypedia	SLC6A7 antibodies

PROTEIN BROWSER

SLC6A7-001	SLC6A7-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC6A7-001 ENSP00000230671 ENST00000230671	Q99884 [Direct mapping] Sodium-dependent proline transporter Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Show all	GO:0005328 [neurotransmitter:sodium symporter activity] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006810 [transport] GO:0006836 [neurotransmitter transport] GO:0015193 [L-proline transmembrane transporter activity] GO:0015824 [proline transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0035524 [proline transmembrane transport] GO:0055085 [transmembrane transport] Show all	636 aa 70.9 kDa	No	>9
SLC6A7-003 ENSP00000428200 ENST00000524041	E5RJL1 [Direct mapping] Transporter Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Show all	GO:0005328 [neurotransmitter:sodium symporter activity] GO:0006836 [neurotransmitter transport] GO:0016021 [integral component of membrane] GO:0055085 [transmembrane transport] Show all	666 aa 73.9 kDa	No	>9

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.