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APBA3

GENERAL INFORMATION

Gene name

 APBA3

Gene description

 Amyloid beta (A4) precursor protein-binding, family A, member 3

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Mixed
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA045577
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable), urothelial cancer (favourable), head and neck cancer (favourable) and endometrial cancer (favourable).
Pancreatic cancer p<0.001
Urothelial cancer p<0.001
Head and neck cancer p<0.001
Endometrial cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA045577

GENE INFORMATION

Gene name

 APBA3 (HGNC Symbol)

Synonyms

 mint3, X11L2

Description

 Amyloid beta (A4) precursor protein-binding, family A, member 3 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene is a member of the X11 protein family. It is an adapter protein that interacts with the Alzheimer's disease amyloid precursor protein. This gene product is believed to be involved in signal transduction processes. This gene is a candidate gene for Alzheimer's disease. [provided by RefSeq, Jul 2008]

Chromosome

 19

Cytoband

 p13.3

Chromosome location (bp)

 3750819 - 3761699

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000011132 (version 83.38)

Entrez gene

 9546

UniProt

 O96018 (UniProt - Evidence at protein level)

neXtProt

 NX_O96018

Antibodypedia

 APBA3 antibodies

PROTEIN BROWSER
APBA3-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
APBA3-001
ENSP00000315136
ENST00000316757
O96018 [Direct mapping]
Amyloid beta A4 precursor protein-binding family A member 3
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Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001540 [beta-amyloid binding]
GO:0001701 [in utero embryonic development]
GO:0004857 [enzyme inhibitor activity]
GO:0005515 [protein binding]
GO:0007268 [synaptic transmission]
GO:0010468 [regulation of gene expression]
GO:0015031 [protein transport]
GO:0019899 [enzyme binding]
GO:0043086 [negative regulation of catalytic activity]
GO:0048471 [perinuclear region of cytoplasm]
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 575 aa
61.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.