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LARS2

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GENERAL INFORMATION

Gene name

 LARS2

Gene description

 Leucyl-tRNA synthetase 2, mitochondrial

Protein class

 Disease related genes
Enzymes
Plasma proteins
Potential drug targets
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the mitochondria. In addition localized to the nucleoplasm.

RNA cell category

 Expressed in all

Protein evidence

 Evidence at protein level

Main location

 Localized to the Mitochondria (supported)

Additional location

 In addition localized to the Nucleoplasm (approved)

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA066085
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ASSAYS
RNA expression
Human cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Expressed in all
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the mitochondria. In addition localized to the nucleoplasm.

Main location

 Mitochondria (supported)

Additional location

 Nucleoplasm (approved)

 

 

 
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Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA066085 U-2 OS Mitochondria
HPA066085 U-251 MG Nucleoplasm
Mitochondria

GENE INFORMATION

Gene name

 LARS2 (HGNC Symbol)

Synonyms

 KIAA0028, LEURS, MGC26121

Description

 Leucyl-tRNA synthetase 2, mitochondrial (HGNC Symbol)

Entrez gene summary

 This gene encodes a class 1 aminoacyl-tRNA synthetase, mitochondrial leucyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid. [provided by RefSeq, Jul 2008]

Chromosome

 3

Cytoband

 p21.31

Chromosome location (bp)

 45388506 - 45549421

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000011376 (version 83.38)

Entrez gene

 23395

UniProt

 Q15031 (UniProt - Evidence at protein level)

neXtProt

 NX_Q15031

Antibodypedia

 LARS2 antibodies

PROTEIN BROWSER
LARS2-001
LARS2-002
LARS2-003
LARS2-005
LARS2-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LARS2-001
ENSP00000265537
ENST00000265537
Q15031 [Direct mapping]
Probable leucine--tRNA ligase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Ligase
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0002161 [aminoacyl-tRNA editing activity]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004823 [leucine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006429 [leucyl-tRNA aminoacylation]
GO:0006450 [regulation of translational fidelity]
GO:0010467 [gene expression]
Show all
 903 aa
102 kDa 		No 0
LARS2-002
ENSP00000408576
ENST00000415258
Q15031 [Direct mapping]
Probable leucine--tRNA ligase, mitochondrial
Show all
Enzymes
   ENZYME proteins
   Ligase
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Disease related genes
Potential drug targets
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0002161 [aminoacyl-tRNA editing activity]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004823 [leucine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0005759 [mitochondrial matrix]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006429 [leucyl-tRNA aminoacylation]
GO:0006450 [regulation of translational fidelity]
GO:0010467 [gene expression]
Show all
 903 aa
102 kDa 		No 0
LARS2-003
ENSP00000412893
ENST00000414984
E9PHM2 [Direct mapping]
Probable leucine--tRNA ligase, mitochondrial
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0002161 [aminoacyl-tRNA editing activity]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004823 [leucine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006429 [leucyl-tRNA aminoacylation]
GO:0006450 [regulation of translational fidelity]
Show all
 860 aa
96.9 kDa 		No 0
LARS2-005
ENSP00000401388
ENST00000430399
C9JYR8 [Direct mapping]
Probable leucine--tRNA ligase, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000166 [nucleotide binding]
GO:0004812 [aminoacyl-tRNA ligase activity]
GO:0004823 [leucine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0006418 [tRNA aminoacylation for protein translation]
GO:0006429 [leucyl-tRNA aminoacylation]
Show all
 114 aa
13.4 kDa 		No 0
LARS2-006
ENSP00000406611
ENST00000431023
C9IZR7 [Direct mapping]
Probable leucine--tRNA ligase, mitochondrial
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004823 [leucine-tRNA ligase activity]
GO:0005524 [ATP binding]
GO:0005739 [mitochondrion]
GO:0006429 [leucyl-tRNA aminoacylation]
Show all
 144 aa
17 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.