Expression of PLAUR in cancer - Summary

GENERAL INFORMATION
Gene name	PLAUR
Gene description	Plasminogen activator, urokinase receptor
Protein class	Cancer-related genes CD markers FDA approved drug targets Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (U-251 MG, U-87 MG, WM-115)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

High cytoplasmic expression in respiratory epithelia and in a subset of cells of bone marrow.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining not consistent with RNA expression data. Presumed off target binding observed and disregarded.
Reliability score	Uncertain based on 1 antibody. HPA050843
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and lung cancer (unfavourable).
Renal cancer p<0.001 Lung cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA050843

GENE INFORMATION
Gene name	PLAUR (HGNC Symbol)
Synonyms	CD87, UPAR, URKR
Description	Plasminogen activator, urokinase receptor (HGNC Symbol)
Entrez gene summary	This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq, Jul 2008]
Chromosome	19
Cytoband	q13.31
Chromosome location (bp)	43646095 - 43670547
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000011422 (version 83.38)
Entrez gene	5329
UniProt	Q03405 (UniProt - Evidence at protein level)
neXtProt	NX_Q03405
Antibodypedia	PLAUR antibodies

PROTEIN BROWSER

PLAUR-001	PLAUR-002	PLAUR-003	PLAUR-006	PLAUR-007	PLAUR-008	PLAUR-009	PLAUR-010	PLAUR-011	PLAUR-012	PLAUR-014

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PLAUR-001 ENSP00000339328 ENST00000340093	Q03405 [Direct mapping] Urokinase plasminogen activator surface receptor Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001934 [positive regulation of protein phosphorylation] GO:0004872 [receptor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005788 [endoplasmic reticulum lumen] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0005925 [focal adhesion] GO:0006501 [C-terminal protein lipidation] GO:0006928 [movement of cell or subcellular component] GO:0006935 [chemotaxis] GO:0007165 [signal transduction] GO:0007596 [blood coagulation] GO:0016021 [integral component of membrane] GO:0016255 [attachment of GPI anchor to protein] GO:0019898 [extrinsic component of membrane] GO:0019899 [enzyme binding] GO:0019904 [protein domain specific binding] GO:0030162 [regulation of proteolysis] GO:0030377 [urokinase plasminogen activator receptor activity] GO:0031225 [anchored component of membrane] GO:0038195 [urokinase plasminogen activator signaling pathway] GO:0042730 [fibrinolysis] GO:0043066 [negative regulation of apoptotic process] GO:0043388 [positive regulation of DNA binding] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0045742 [positive regulation of epidermal growth factor receptor signaling pathway] GO:0070062 [extracellular exosome] GO:0071438 [invadopodium membrane] GO:0090200 [positive regulation of release of cytochrome c from mitochondria] GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway] GO:2001268 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway] Show all	335 aa 37 kDa	Yes	1
PLAUR-002 ENSP00000221264 ENST00000221264	Q03405 [Direct mapping] Urokinase plasminogen activator surface receptor Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001934 [positive regulation of protein phosphorylation] GO:0004872 [receptor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005788 [endoplasmic reticulum lumen] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006501 [C-terminal protein lipidation] GO:0006928 [movement of cell or subcellular component] GO:0006935 [chemotaxis] GO:0007165 [signal transduction] GO:0007596 [blood coagulation] GO:0016021 [integral component of membrane] GO:0016255 [attachment of GPI anchor to protein] GO:0019898 [extrinsic component of membrane] GO:0019899 [enzyme binding] GO:0019904 [protein domain specific binding] GO:0030162 [regulation of proteolysis] GO:0030377 [urokinase plasminogen activator receptor activity] GO:0031225 [anchored component of membrane] GO:0038195 [urokinase plasminogen activator signaling pathway] GO:0042730 [fibrinolysis] GO:0043066 [negative regulation of apoptotic process] GO:0043388 [positive regulation of DNA binding] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0045742 [positive regulation of epidermal growth factor receptor signaling pathway] GO:0070062 [extracellular exosome] GO:0071438 [invadopodium membrane] GO:0090200 [positive regulation of release of cytochrome c from mitochondria] GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway] GO:2001268 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway] Show all	290 aa 32 kDa	Yes	1
PLAUR-003 ENSP00000342049 ENST00000339082	Q03405 [Direct mapping] Urokinase plasminogen activator surface receptor Show all	CD markers Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Cancer-related genes Candidate cancer biomarkers FDA approved drug targets Biotech drugs Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001934 [positive regulation of protein phosphorylation] GO:0004872 [receptor activity] GO:0005102 [receptor binding] GO:0005515 [protein binding] GO:0005788 [endoplasmic reticulum lumen] GO:0005789 [endoplasmic reticulum membrane] GO:0005886 [plasma membrane] GO:0005925 [focal adhesion] GO:0006501 [C-terminal protein lipidation] GO:0006928 [movement of cell or subcellular component] GO:0006935 [chemotaxis] GO:0007165 [signal transduction] GO:0007596 [blood coagulation] GO:0016021 [integral component of membrane] GO:0016255 [attachment of GPI anchor to protein] GO:0019898 [extrinsic component of membrane] GO:0019899 [enzyme binding] GO:0019904 [protein domain specific binding] GO:0030162 [regulation of proteolysis] GO:0030377 [urokinase plasminogen activator receptor activity] GO:0031225 [anchored component of membrane] GO:0038195 [urokinase plasminogen activator signaling pathway] GO:0042730 [fibrinolysis] GO:0043066 [negative regulation of apoptotic process] GO:0043388 [positive regulation of DNA binding] GO:0043687 [post-translational protein modification] GO:0044267 [cellular protein metabolic process] GO:0045742 [positive regulation of epidermal growth factor receptor signaling pathway] GO:0070062 [extracellular exosome] GO:0071438 [invadopodium membrane] GO:0090200 [positive regulation of release of cytochrome c from mitochondria] GO:2001243 [negative regulation of intrinsic apoptotic signaling pathway] GO:2001268 [negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway] Show all	281 aa 31.3 kDa	Yes	0
PLAUR-006 ENSP00000470029 ENST00000599892	M0QYR6 [Direct mapping] Urokinase plasminogen activator surface receptor Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		226 aa 25.2 kDa	No	0
PLAUR-007 ENSP00000472511 ENST00000593939	M0R2E9 [Direct mapping] Urokinase plasminogen activator surface receptor Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		152 aa 17.2 kDa	No	0
PLAUR-008 ENSP00000468863 ENST00000599546	M0QX27 [Direct mapping] Urokinase plasminogen activator surface receptor Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		78 aa 8.9 kDa	No	0
PLAUR-009 ENSP00000471241 ENST00000602141	M0R0H5 [Direct mapping] Urokinase plasminogen activator surface receptor Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		153 aa 17.1 kDa	No	0
PLAUR-010 ENSP00000473055 ENST00000595038	M0R383 [Direct mapping] Urokinase plasminogen activator surface receptor Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		154 aa 16.8 kDa	No	0
PLAUR-011 ENSP00000470050 ENST00000593447	M0QYS6 [Direct mapping] Urokinase plasminogen activator surface receptor Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		133 aa 14.9 kDa	No	0
PLAUR-012 ENSP00000471881 ENST00000601723	M0R1I2 [Direct mapping] Urokinase plasminogen activator surface receptor Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		286 aa 31.6 kDa	Yes	1
PLAUR-014 ENSP00000471525 ENST00000593714	M0R0Y4 [Direct mapping] Urokinase plasminogen activator surface receptor Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		185 aa 20.6 kDa	No	0