Expression of RABGAP1 in cancer - Summary - The Human Protein Atlas

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RABGAP1

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	RABGAP1
Gene description	RAB GTPase activating protein 1
Protein class	Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Caution, targets protein from more than one gene.
Reliability score	Approved based on 1 antibody. HPA041651
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable) and breast cancer (unfavourable).
Renal cancer p<0.001 Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA041651

GENE INFORMATION
Gene name	RABGAP1 (HGNC Symbol)
Synonyms	GAPCenA, TBC1D11
Description	RAB GTPase activating protein 1 (HGNC Symbol)
Entrez gene summary
Chromosome	9
Cytoband
Chromosome location (bp)	122940833 - 123104866
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000011454 (version 83.38)
Entrez gene	23637
UniProt	Q9Y3P9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9Y3P9
Antibodypedia	RABGAP1 antibodies

PROTEIN BROWSER

RABGAP1-001	RABGAP1-006	RABGAP1-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RABGAP1-001 ENSP00000362751 ENST00000373647	Q9Y3P9 [Direct mapping] Rab GTPase-activating protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003677 [DNA binding] GO:0005096 [GTPase activator activity] GO:0005515 [protein binding] GO:0005813 [centrosome] GO:0005829 [cytosol] GO:0005875 [microtubule associated complex] GO:0007049 [cell cycle] GO:0015631 [tubulin binding] GO:0017137 [Rab GTPase binding] GO:0043547 [positive regulation of GTPase activity] Show all	1069 aa 121.7 kDa	No	2
RABGAP1-006 ENSP00000384119 ENST00000402311	B5MCD9 [Direct mapping] Rab GTPase-activating protein 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		112 aa 11.8 kDa	No	0
RABGAP1-201 ENSP00000482287 ENST00000616002	H9NIL4 [Direct mapping] G protein-coupled receptor 21; Rab GTPase-activating protein 1 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] Show all	349 aa 39.5 kDa	No	7

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.