Expression of MAP4K3 in cancer - Summary - The Human Protein Atlas

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MAP4K3

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MAP4K3
Gene description	Mitogen-activated protein kinase kinase kinase kinase 3
Protein class	Cancer-related genes Enzymes Plasma proteins Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA030380
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA030380

GENE INFORMATION
Gene name	MAP4K3 (HGNC Symbol)
Synonyms	GLK, MAPKKKK3, RAB8IPL1
Description	Mitogen-activated protein kinase kinase kinase kinase 3 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]
Chromosome	2
Cytoband	p22.1
Chromosome location (bp)	39249266 - 39437312
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000011566 (version 83.38)
Entrez gene	8491
UniProt	Q8IVH8 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IVH8
Antibodypedia	MAP4K3 antibodies

PROTEIN BROWSER

MAP4K3-001	MAP4K3-002	MAP4K3-006	MAP4K3-014

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MAP4K3-001 ENSP00000263881 ENST00000263881	Q8IVH8 [Direct mapping] Mitogen-activated protein kinase kinase kinase kinase 3 Show all	Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000185 [activation of MAPKKK activity] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0007254 [JNK cascade] GO:0007346 [regulation of mitotic cell cycle] GO:0008349 [MAP kinase kinase kinase kinase activity] GO:0009411 [response to UV] GO:0032147 [activation of protein kinase activity] GO:0034612 [response to tumor necrosis factor] GO:0035556 [intracellular signal transduction] GO:0042981 [regulation of apoptotic process] Show all	894 aa 101.3 kDa	No	0
MAP4K3-002 ENSP00000476533 ENST00000484274	V9GY95 [Direct mapping] Mitogen-activated protein kinase kinase kinase kinase 3 Show all	Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0000185 [activation of MAPKKK activity] GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0007346 [regulation of mitotic cell cycle] GO:0008349 [MAP kinase kinase kinase kinase activity] GO:0032147 [activation of protein kinase activity] GO:0042981 [regulation of apoptotic process] Show all	92 aa 10.6 kDa	No	0
MAP4K3-006 ENSP00000345434 ENST00000341681	Q8IVH8 [Direct mapping] Mitogen-activated protein kinase kinase kinase kinase 3 Show all	Enzymes ENZYME proteins Transferases Kinases STE Ser/Thr protein kinases MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Plasma proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000185 [activation of MAPKKK activity] GO:0004672 [protein kinase activity] GO:0004674 [protein serine/threonine kinase activity] GO:0005515 [protein binding] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0007254 [JNK cascade] GO:0007346 [regulation of mitotic cell cycle] GO:0008349 [MAP kinase kinase kinase kinase activity] GO:0009411 [response to UV] GO:0032147 [activation of protein kinase activity] GO:0034612 [response to tumor necrosis factor] GO:0035556 [intracellular signal transduction] GO:0042981 [regulation of apoptotic process] Show all	873 aa 99 kDa	No	0
MAP4K3-014 ENSP00000416958 ENST00000437545	F5H5A3 [Direct mapping] Mitogen-activated protein kinase kinase kinase kinase Show all	MEMSAT-SVM predicted membrane proteins Predicted intracellular proteins Cancer-related genes Mutated cancer genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0000165 [MAPK cascade] GO:0000185 [activation of MAPKKK activity] GO:0004672 [protein kinase activity] GO:0005524 [ATP binding] GO:0005737 [cytoplasm] GO:0006468 [protein phosphorylation] GO:0007346 [regulation of mitotic cell cycle] GO:0008349 [MAP kinase kinase kinase kinase activity] GO:0032147 [activation of protein kinase activity] GO:0042981 [regulation of apoptotic process] Show all	810 aa 91.9 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.