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LTF

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GENERAL INFORMATION

Gene name

 LTF

Gene description

 Lactotransferrin

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Secreted

Number of transcripts

 5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

RNA cell category

 Group enriched (RPMI-8226, TIME)

Protein evidence

 Evidence at protein level

Main location

 Not available

DATA RELIABILITY

Reliability score

 Pending cell analysis.

ASSAYS
RNA expression

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (RPMI-8226, TIME)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

GENE INFORMATION

Gene name

 LTF (HGNC Symbol)

Synonyms

 HLF2

Description

 Lactotransferrin (HGNC Symbol)

Entrez gene summary

 This gene is a member of the transferrin family of genes and its protein product is found in the secondary granules of neutrophils. The protein is a major iron-binding protein in milk and body secretions with an antimicrobial activity, making it an important component of the non-specific immune system. The protein demonstrates a broad spectrum of properties, including regulation of iron homeostasis, host defense against a broad range of microbial infections, anti-inflammatory activity, regulation of cellular growth and differentiation and protection against cancer development and metastasis. Antimicrobial, antiviral, antifungal and antiparasitic activity has been found for this protein and its peptides. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

Chromosome

 3

Cytoband

 p21.31

Chromosome location (bp)

 46435645 - 46485234

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000012223 (version 83.38)

Entrez gene

 4057

UniProt

 P02788 (UniProt - Evidence at protein level)

neXtProt

 NX_P02788

Antibodypedia

 LTF antibodies

PROTEIN BROWSER
LTF-001
LTF-002
LTF-003
LTF-005
LTF-011

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
LTF-001
ENSP00000231751
ENST00000231751
P02788 [Direct mapping]
Lactotransferrin Lactoferricin-H Kaliocin-1 Lactoferroxin-A Lactoferroxin-B Lactoferroxin-C
V9HWI4 [Target identity:100%; Query identity:100%]
Epididymis luminal protein 110
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001503 [ossification]
GO:0001817 [regulation of cytokine production]
GO:0001895 [retina homeostasis]
GO:0002227 [innate immune response in mucosa]
GO:0003677 [DNA binding]
GO:0004252 [serine-type endopeptidase activity]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006508 [proteolysis]
GO:0006811 [ion transport]
GO:0006959 [humoral immune response]
GO:0008201 [heparin binding]
GO:0008233 [peptidase activity]
GO:0009986 [cell surface]
GO:0019731 [antibacterial humoral response]
GO:0019732 [antifungal humoral response]
GO:0030141 [secretory granule]
GO:0031665 [negative regulation of lipopolysaccharide-mediated signaling pathway]
GO:0032680 [regulation of tumor necrosis factor production]
GO:0032780 [negative regulation of ATPase activity]
GO:0033214 [iron assimilation by chelation and transport]
GO:0033690 [positive regulation of osteoblast proliferation]
GO:0034145 [positive regulation of toll-like receptor 4 signaling pathway]
GO:0042581 [specific granule]
GO:0043066 [negative regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043234 [protein complex]
GO:0043539 [protein serine/threonine kinase activator activity]
GO:0044267 [cellular protein metabolic process]
GO:0044793 [negative regulation by host of viral process]
GO:0045071 [negative regulation of viral genome replication]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0048525 [negative regulation of viral process]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051701 [interaction with host]
GO:0052572 [response to host immune response]
GO:0060349 [bone morphogenesis]
GO:0070062 [extracellular exosome]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0090382 [phagosome maturation]
GO:0097013 [phagocytic vesicle lumen]
GO:1900159 [positive regulation of bone mineralization involved in bone maturation]
GO:1900229 [negative regulation of single-species biofilm formation in or on host organism]
GO:1902732 [positive regulation of chondrocyte proliferation]
GO:2000308 [negative regulation of tumor necrosis factor (ligand) superfamily member 11 production]
GO:2001205 [negative regulation of osteoclast development]
Show all
 710 aa
78.2 kDa 		Yes 0
LTF-002
ENSP00000397427
ENST00000443496
E7EQB2 [Direct mapping]
Lactotransferrin
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001817 [regulation of cytokine production]
GO:0004252 [serine-type endopeptidase activity]
GO:0005506 [iron ion binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006508 [proteolysis]
GO:0019731 [antibacterial humoral response]
GO:0019732 [antifungal humoral response]
Show all
 696 aa
76.6 kDa 		No 0
LTF-003
ENSP00000405546
ENST00000417439
E7ER44 [Direct mapping]
Lactotransferrin
Show all
   MEMSAT3 predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001817 [regulation of cytokine production]
GO:0004252 [serine-type endopeptidase activity]
GO:0005506 [iron ion binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0006508 [proteolysis]
GO:0019731 [antibacterial humoral response]
GO:0019732 [antifungal humoral response]
Show all
 708 aa
78 kDa 		Yes 0
LTF-005
ENSP00000395234
ENST00000431944
C9JCF5 [Direct mapping]
Lactotransferrin
Show all
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005576 [extracellular region]
Show all
 182 aa
20.3 kDa 		Yes 0
LTF-011
ENSP00000405719
ENST00000426532
P02788 [Direct mapping]
Lactotransferrin Lactoferricin-H Kaliocin-1 Lactoferroxin-A Lactoferroxin-B Lactoferroxin-C
Show all
Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0001503 [ossification]
GO:0001817 [regulation of cytokine production]
GO:0001895 [retina homeostasis]
GO:0002227 [innate immune response in mucosa]
GO:0003677 [DNA binding]
GO:0004252 [serine-type endopeptidase activity]
GO:0005506 [iron ion binding]
GO:0005515 [protein binding]
GO:0005576 [extracellular region]
GO:0005615 [extracellular space]
GO:0005634 [nucleus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006508 [proteolysis]
GO:0006811 [ion transport]
GO:0006959 [humoral immune response]
GO:0008201 [heparin binding]
GO:0009986 [cell surface]
GO:0019731 [antibacterial humoral response]
GO:0019732 [antifungal humoral response]
GO:0030141 [secretory granule]
GO:0031665 [negative regulation of lipopolysaccharide-mediated signaling pathway]
GO:0032680 [regulation of tumor necrosis factor production]
GO:0032780 [negative regulation of ATPase activity]
GO:0033214 [iron assimilation by chelation and transport]
GO:0033690 [positive regulation of osteoblast proliferation]
GO:0034145 [positive regulation of toll-like receptor 4 signaling pathway]
GO:0042581 [specific granule]
GO:0043066 [negative regulation of apoptotic process]
GO:0043123 [positive regulation of I-kappaB kinase/NF-kappaB signaling]
GO:0043234 [protein complex]
GO:0043539 [protein serine/threonine kinase activator activity]
GO:0044267 [cellular protein metabolic process]
GO:0044793 [negative regulation by host of viral process]
GO:0045071 [negative regulation of viral genome replication]
GO:0045669 [positive regulation of osteoblast differentiation]
GO:0048525 [negative regulation of viral process]
GO:0051092 [positive regulation of NF-kappaB transcription factor activity]
GO:0051701 [interaction with host]
GO:0052572 [response to host immune response]
GO:0060349 [bone morphogenesis]
GO:0070062 [extracellular exosome]
GO:0071902 [positive regulation of protein serine/threonine kinase activity]
GO:0090382 [phagosome maturation]
GO:0097013 [phagocytic vesicle lumen]
GO:1900159 [positive regulation of bone mineralization involved in bone maturation]
GO:1900229 [negative regulation of single-species biofilm formation in or on host organism]
GO:1902732 [positive regulation of chondrocyte proliferation]
GO:2000308 [negative regulation of tumor necrosis factor (ligand) superfamily member 11 production]
GO:2001205 [negative regulation of osteoclast development]
Show all
 666 aa
73.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.