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NR1H4

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GENERAL INFORMATION

Gene name

 NR1H4

Gene description

 Nuclear receptor subfamily 1, group H, member 4

Protein class

 Nuclear receptors
Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 7
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

Summary

 Localized to the nucleoplasm.

RNA cell category

 Group enriched (RPTEC TERT1, Hep G2)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleoplasm (approved)

Mouse

 Localized to the Nucleus in mouse cells.

DATA RELIABILITY

Reliability score

 Approved based on 1 antibody.
HPA047699
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ASSAYS
RNA expression
Human cells
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Group enriched (RPTEC TERT1, Hep G2)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Localized to the nucleoplasm.

Main location

 Nucleoplasm (approved)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA047699 A549 Nucleoplasm
HPA047699 Hep G2 Nucleoplasm
HPA047699 U-2 OS Nucleoplasm

MOUSE CELLS

Main location

 Nucleus

Mouse gene

 ENSMUSG00000047638 (version 83)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location
HPA047699 NIH 3T3 Nucleus

GENE INFORMATION

Gene name

 NR1H4 (HGNC Symbol)

Synonyms

 FXR, HRR-1, HRR1, RIP14

Description

 Nuclear receptor subfamily 1, group H, member 4 (HGNC Symbol)

Entrez gene summary

 This gene encodes a ligand-activated transcription factor, which shares structural features in common with nuclear hormone receptor family, such as a DNA-binding domain that targets the receptor to specific DNA sequences, and a ligand-binding domain, which interacts directly with the ligand and contains a ligand-dependent transcriptional activation domain. This protein functions as a receptor for bile acids, and when bound to bile acids, regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

Chromosome

 12

Cytoband

 q23.1

Chromosome location (bp)

 100473708 - 100564413

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000012504 (version 83.38)

Entrez gene

 9971

UniProt

 Q96RI1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q96RI1

Antibodypedia

 NR1H4 antibodies

PROTEIN BROWSER
NR1H4-001
NR1H4-002
NR1H4-003
NR1H4-005
NR1H4-006
NR1H4-007
NR1H4-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
NR1H4-001
ENSP00000448506
ENST00000548884
Q96RI1 [Direct mapping]
Bile acid receptor
B6ZGS9 [Target identity:100%; Query identity:100%]
Farnesoid X receptor; Nuclear receptor subfamily 1, group H, member 4, isoform CRA_a
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001080 [nitrogen catabolite activation of transcription from RNA polymerase II promoter]
GO:0001190 [transcriptional activator activity, RNA polymerase II transcription factor binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0004887 [thyroid hormone receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005719 [nuclear euchromatin]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0008206 [bile acid metabolic process]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0015721 [bile acid and bile salt transport]
GO:0016922 [ligand-dependent nuclear receptor binding]
GO:0030522 [intracellular receptor signaling pathway]
GO:0032052 [bile acid binding]
GO:0034255 [regulation of urea metabolic process]
GO:0038181 [bile acid receptor activity]
GO:0038185 [intracellular bile acid receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0044281 [small molecule metabolic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0070857 [regulation of bile acid biosynthetic process]
GO:0070858 [negative regulation of bile acid biosynthetic process]
GO:0071417 [cellular response to organonitrogen compound]
GO:0090181 [regulation of cholesterol metabolic process]
GO:1902122 [chenodeoxycholic acid binding]
GO:1903413 [cellular response to bile acid]
GO:2000213 [positive regulation of glutamate metabolic process]
Show all
 472 aa
54.4 kDa 		No 0
NR1H4-002
ENSP00000448978
ENST00000549996
Q96RI1 [Direct mapping]
Bile acid receptor
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001080 [nitrogen catabolite activation of transcription from RNA polymerase II promoter]
GO:0001190 [transcriptional activator activity, RNA polymerase II transcription factor binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0004887 [thyroid hormone receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005719 [nuclear euchromatin]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0008206 [bile acid metabolic process]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0015721 [bile acid and bile salt transport]
GO:0016922 [ligand-dependent nuclear receptor binding]
GO:0030522 [intracellular receptor signaling pathway]
GO:0032052 [bile acid binding]
GO:0034255 [regulation of urea metabolic process]
GO:0038181 [bile acid receptor activity]
GO:0038185 [intracellular bile acid receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0044281 [small molecule metabolic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0070857 [regulation of bile acid biosynthetic process]
GO:0070858 [negative regulation of bile acid biosynthetic process]
GO:0071417 [cellular response to organonitrogen compound]
GO:0090181 [regulation of cholesterol metabolic process]
GO:1902122 [chenodeoxycholic acid binding]
GO:1903413 [cellular response to bile acid]
GO:2000213 [positive regulation of glutamate metabolic process]
Show all
 425 aa
48.8 kDa 		No 0
NR1H4-003
ENSP00000376712
ENST00000392986
Q96RI1 [Direct mapping]
Bile acid receptor
F1DAL1 [Target identity:100%; Query identity:100%]
Farnesoid X nuclear receptor; Nuclear receptor subfamily 1, group H, member 4, isoform CRA_b
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001080 [nitrogen catabolite activation of transcription from RNA polymerase II promoter]
GO:0001190 [transcriptional activator activity, RNA polymerase II transcription factor binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0004887 [thyroid hormone receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005719 [nuclear euchromatin]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0008206 [bile acid metabolic process]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0015721 [bile acid and bile salt transport]
GO:0016922 [ligand-dependent nuclear receptor binding]
GO:0030522 [intracellular receptor signaling pathway]
GO:0032052 [bile acid binding]
GO:0034255 [regulation of urea metabolic process]
GO:0038181 [bile acid receptor activity]
GO:0038185 [intracellular bile acid receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0044281 [small molecule metabolic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0070857 [regulation of bile acid biosynthetic process]
GO:0070858 [negative regulation of bile acid biosynthetic process]
GO:0071417 [cellular response to organonitrogen compound]
GO:0090181 [regulation of cholesterol metabolic process]
GO:1902122 [chenodeoxycholic acid binding]
GO:1903413 [cellular response to bile acid]
GO:2000213 [positive regulation of glutamate metabolic process]
Show all
 476 aa
54.9 kDa 		No 0
NR1H4-005
ENSP00000188403
ENST00000188403
Q96RI1 [Direct mapping]
Bile acid receptor
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001080 [nitrogen catabolite activation of transcription from RNA polymerase II promoter]
GO:0001190 [transcriptional activator activity, RNA polymerase II transcription factor binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0004887 [thyroid hormone receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005719 [nuclear euchromatin]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0008206 [bile acid metabolic process]
GO:0008270 [zinc ion binding]
GO:0010467 [gene expression]
GO:0015721 [bile acid and bile salt transport]
GO:0016922 [ligand-dependent nuclear receptor binding]
GO:0030522 [intracellular receptor signaling pathway]
GO:0032052 [bile acid binding]
GO:0034255 [regulation of urea metabolic process]
GO:0038181 [bile acid receptor activity]
GO:0038185 [intracellular bile acid receptor signaling pathway]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0044281 [small molecule metabolic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0070857 [regulation of bile acid biosynthetic process]
GO:0070858 [negative regulation of bile acid biosynthetic process]
GO:0071417 [cellular response to organonitrogen compound]
GO:0090181 [regulation of cholesterol metabolic process]
GO:1902122 [chenodeoxycholic acid binding]
GO:1903413 [cellular response to bile acid]
GO:2000213 [positive regulation of glutamate metabolic process]
Show all
 482 aa
55.5 kDa 		No 0
NR1H4-006
ENSP00000447149
ENST00000551379
Q96RI1 [Direct mapping]
Bile acid receptor
Show all
Nuclear receptors
Predicted intracellular proteins
Transcription factors
   Zinc-coordinating DNA-binding domains
Protein evidence (Kim et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000980 [RNA polymerase II distal enhancer sequence-specific DNA binding]
GO:0001077 [transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0001080 [nitrogen catabolite activation of transcription from RNA polymerase II promoter]
GO:0001190 [transcriptional activator activity, RNA polymerase II transcription factor binding]
GO:0003677 [DNA binding]
GO:0003690 [double-stranded DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0003705 [transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding]
GO:0003707 [steroid hormone receptor activity]
GO:0003713 [transcription coactivator activity]
GO:0003714 [transcription corepressor activity]
GO:0004872 [receptor activity]
GO:0004879 [RNA polymerase II transcription factor activity, ligand-activated sequence-specific DNA binding]
GO:0004887 [thyroid hormone receptor activity]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005654 [nucleoplasm]
GO:0005719 [nuclear euchromatin]
GO:0006109 [regulation of carbohydrate metabolic process]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006367 [transcription initiation from RNA polymerase II promoter]
GO:0007165 [signal transduction]
GO:0007219 [Notch signaling pathway]
GO:0008206 [bile acid metabolic process]
GO:0008270 [zinc ion binding]
GO:0009749 [response to glucose]
GO:0010467 [gene expression]
GO:0015721 [bile acid and bile salt transport]
GO:0016922 [ligand-dependent nuclear receptor binding]
GO:0030522 [intracellular receptor signaling pathway]
GO:0032052 [bile acid binding]
GO:0032496 [response to lipopolysaccharide]
GO:0034255 [regulation of urea metabolic process]
GO:0038181 [bile acid receptor activity]
GO:0038185 [intracellular bile acid receptor signaling pathway]
GO:0042277 [peptide binding]
GO:0043401 [steroid hormone mediated signaling pathway]
GO:0043565 [sequence-specific DNA binding]
GO:0044281 [small molecule metabolic process]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046965 [retinoid X receptor binding]
GO:0048565 [digestive tract development]
GO:0070857 [regulation of bile acid biosynthetic process]
GO:0070858 [negative regulation of bile acid biosynthetic process]
GO:0071417 [cellular response to organonitrogen compound]
GO:0090181 [regulation of cholesterol metabolic process]
GO:1902122 [chenodeoxycholic acid binding]
GO:1903413 [cellular response to bile acid]
GO:2000213 [positive regulation of glutamate metabolic process]
GO:2001250 [positive regulation of ammonia assimilation cycle]
Show all
 486 aa
55.9 kDa 		No 0
NR1H4-007
ENSP00000446861
ENST00000551184
H0YHD5 [Direct mapping]
Bile acid receptor
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Show all
 34 aa
3.8 kDa 		No 0
NR1H4-008
ENSP00000446760
ENST00000546380
F8W1M1 [Direct mapping]
Bile acid receptor
Show all
Predicted intracellular proteins
Show all
 45 aa
5.2 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.