Expression of KDM5D in cancer - Summary - The Human Protein Atlas

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KDM5D

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	KDM5D
Gene description	Lysine (K)-specific demethylase 5D
Protein class	Plasma proteins Predicted intracellular proteins Transcription factors
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (HEL)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY
Data reliability description	RNA-based expert annotation gave inconclusive results. Pending external verification.
Reliability score	Uncertain based on 2 antibodies. HPA049086 , HPA060807
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (favourable).
Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA049086	HPA060807

GENE INFORMATION
Gene name	KDM5D (HGNC Symbol)
Synonyms	HY, HYA, JARID1D, KIAA0234, SMCY
Description	Lysine (K)-specific demethylase 5D (HGNC Symbol)
Entrez gene summary	This gene encodes a protein containing zinc finger domains. A short peptide derived from this protein is a minor histocompatibility antigen which can lead to graft rejection of male donor cells in a female recipient. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]
Chromosome	Y
Cytoband	q11.223
Chromosome location (bp)	19703865 - 19744939
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000012817 (version 83.38)
Entrez gene	8284
UniProt	Q9BY66 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BY66
Antibodypedia	KDM5D antibodies

PROTEIN BROWSER

KDM5D-001	KDM5D-002	KDM5D-003	KDM5D-004	KDM5D-009	KDM5D-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
KDM5D-001 ENSP00000322408 ENST00000317961	Q9BY66 [Direct mapping] Lysine-specific demethylase 5D Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Show all	GO:0002457 [T cell antigen processing and presentation] GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0005654 [nucleoplasm] GO:0006325 [chromatin organization] GO:0008270 [zinc ion binding] GO:0016706 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors] GO:0032453 [histone demethylase activity (H3-K4 specific)] GO:0034720 [histone H3-K4 demethylation] GO:0055114 [oxidation-reduction process] Show all	1539 aa 174.1 kDa	No	0
KDM5D-002 ENSP00000372256 ENST00000382806	Q9BY66 [Direct mapping] Lysine-specific demethylase 5D Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0005654 [nucleoplasm] GO:0006325 [chromatin organization] GO:0008270 [zinc ion binding] GO:0016706 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors] GO:0032453 [histone demethylase activity (H3-K4 specific)] GO:0034720 [histone H3-K4 demethylation] GO:0055114 [oxidation-reduction process] Show all	1482 aa 167.4 kDa	No	0
KDM5D-003 ENSP00000416377 ENST00000447300	C9JGA3 [Direct mapping] Lysine-specific demethylase 5D Show all	Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0008270 [zinc ion binding] Show all	425 aa 48.5 kDa	No	0
KDM5D-004 ENSP00000398543 ENST00000440077	E9PFH2 [Direct mapping] Lysine-specific demethylase 5D Show all	THUMBUP predicted membrane proteins Predicted intracellular proteins Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0008270 [zinc ion binding] GO:0016706 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors] GO:0055114 [oxidation-reduction process] Show all	1476 aa 166.9 kDa	No	0
KDM5D-009 ENSP00000389433 ENST00000415360	H7BZF9 [Direct mapping] Lysine-specific demethylase 5D Show all	Predicted intracellular proteins Show all	GO:0005515 [protein binding] GO:0008270 [zinc ion binding] GO:0016706 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors] GO:0055114 [oxidation-reduction process] Show all	293 aa 32.2 kDa	No	0
KDM5D-201 ENSP00000444293 ENST00000541639	Q9BY66 [Direct mapping] Lysine-specific demethylase 5D Show all	SCAMPI predicted membrane proteins THUMBUP predicted membrane proteins Predicted intracellular proteins Plasma proteins Transcription factors Helix-turn-helix domains Protein evidence (Kim et al 2014) Show all	GO:0003677 [DNA binding] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0005654 [nucleoplasm] GO:0006325 [chromatin organization] GO:0008270 [zinc ion binding] GO:0016706 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors] GO:0032453 [histone demethylase activity (H3-K4 specific)] GO:0034720 [histone H3-K4 demethylation] GO:0055114 [oxidation-reduction process] Show all	1570 aa 177.6 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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