Expression of SLC7A14 in cancer - Summary - The Human Protein Atlas

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SLC7A14

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SLC7A14
Gene description	Solute carrier family 7, member 14
Protein class	Disease related genes Potential drug targets Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Group enriched (glioma, pancreatic cancer)
HPA (cell line):	Cell line enhanced (LHCN-M2, SCLC-21H)
HPA (normal tissue):	Tissue enriched (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in processes of hippocampus.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Antibody staining in cells/structures not annotated, view images.
Reliability score	Approved based on 1 antibody. HPA045929
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Group enriched (glioma, pancreatic cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA045929

GENE INFORMATION
Gene name	SLC7A14 (HGNC Symbol)
Synonyms	KIAA1613, PPP1R142
Description	Solute carrier family 7, member 14 (HGNC Symbol)
Entrez gene summary	This gene is predicted to encode a glycosylated, cationic amino acid transporter protein with 14 transmembrane domains. This gene is primarily expressed in skin fibroblasts, neural tissue, and primary endothelial cells and its protein is predicted to mediate lysosomal uptake of cationic amino acids. Mutations in this gene are associated with autosomal recessive retinitis pigmentosa. In mice, this gene is expressed in the photoreceptor layer of the retina where its expression increases over the course of retinal development and persists in the mature retina. [provided by RefSeq, Apr 2014]
Chromosome	3
Cytoband	q26.2
Chromosome location (bp)	170459584 - 170586074
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000013293 (version 83.38)
Entrez gene	57709
UniProt	Q8TBB6 (UniProt - Evidence at transcript level)
neXtProt	NX_Q8TBB6
Antibodypedia	SLC7A14 antibodies

PROTEIN BROWSER

SLC7A14-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC7A14-001 ENSP00000231706 ENST00000231706	Q8TBB6 [Direct mapping] Probable cationic amino acid transporter Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Show all	GO:0003333 [amino acid transmembrane transport] GO:0005765 [lysosomal membrane] GO:0005887 [integral component of plasma membrane] GO:0010923 [negative regulation of phosphatase activity] GO:0015171 [amino acid transmembrane transporter activity] GO:0015179 [L-amino acid transmembrane transporter activity] GO:0015297 [antiporter activity] GO:0015807 [L-amino acid transport] GO:0016020 [membrane] GO:1902475 [L-alpha-amino acid transmembrane transport] Show all	771 aa 84.1 kDa	No	>9

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.