Expression of CLDN11 in cancer - Summary - The Human Protein Atlas

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CLDN11

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CLDN11
Gene description	Claudin 11
Protein class	Predicted membrane proteins
Predicted localization	Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enhanced (glioma)
HPA (cell line):	Group enriched (ASC TERT1, EFO-21, HUVEC TERT2, TIME)
HPA (normal tissue):	Tissue enhanced (cerebral cortex, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous expression in sertoli cells in testis and oligodendrocytes in the CNS.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA013166 , CAB009789
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PROGNOSTIC SUMMARY
Prognostic marker in breast cancer (favourable).
Breast cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enhanced (glioma)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA013166	CAB009789

GENE INFORMATION
Gene name	CLDN11 (HGNC Symbol)
Synonyms	OSP, OTM
Description	Claudin 11 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Aug 2010]
Chromosome	3
Cytoband	q26.2
Chromosome location (bp)	170418865 - 170860380
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000013297 (version 83.38)
Entrez gene	5010
UniProt	O75508 (UniProt - Evidence at transcript level)
neXtProt	NX_O75508
Antibodypedia	CLDN11 antibodies

PROTEIN BROWSER

CLDN11-001	CLDN11-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CLDN11-001 ENSP00000064724 ENST00000064724	O75508 [Direct mapping] Claudin-11 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005923 [bicellular tight junction] GO:0007155 [cell adhesion] GO:0007283 [spermatogenesis] GO:0008366 [axon ensheathment] GO:0016021 [integral component of membrane] GO:0016338 [calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules] GO:0042802 [identical protein binding] GO:0043209 [myelin sheath] GO:0045178 [basal part of cell] GO:0070062 [extracellular exosome] Show all	207 aa 22 kDa	No	4
CLDN11-002 ENSP00000417434 ENST00000486975	B4DFI2 [Direct mapping] Claudin Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005198 [structural molecule activity] GO:0005886 [plasma membrane] GO:0005923 [bicellular tight junction] GO:0016021 [integral component of membrane] Show all	165 aa 18 kDa	No	3

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.