Expression of ANGEL1 in cancer - Summary - The Human Protein Atlas

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ANGEL1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ANGEL1
Gene description	Angel homolog 1 (Drosophila)
Protein class	Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in a few tissues, most abundant in testis.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Uncertain based on 1 antibody. HPA000948
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PROGNOSTIC SUMMARY
Prognostic marker in lung cancer (favourable) and pancreatic cancer (favourable).
Lung cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA000948

GENE INFORMATION
Gene name	ANGEL1 (HGNC Symbol)
Synonyms	Ccr4e, KIAA0759
Description	Angel homolog 1 (Drosophila) (HGNC Symbol)
Entrez gene summary
Chromosome	14
Cytoband	q24.3
Chromosome location (bp)	76786178 - 76826246
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000013523 (version 83.38)
Entrez gene	23357
UniProt	Q9UNK9 (UniProt - Evidence at transcript level)
neXtProt	NX_Q9UNK9
Antibodypedia	ANGEL1 antibodies

PROTEIN BROWSER

ANGEL1-001	ANGEL1-003	ANGEL1-005	ANGEL1-007

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ANGEL1-001 ENSP00000251089 ENST00000251089	Q9UNK9 [Direct mapping] Protein angel homolog 1 A0A024R6B2 [Target identity:100%; Query identity:100%] Angel homolog 1 (Drosophila), isoform CRA_b Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005634 [nucleus] GO:0005783 [endoplasmic reticulum] GO:0005801 [cis-Golgi network] GO:0005829 [cytosol] GO:0008190 [eukaryotic initiation factor 4E binding] GO:0019904 [protein domain specific binding] GO:0048471 [perinuclear region of cytoplasm] Show all	670 aa 75.3 kDa	Yes	0
ANGEL1-003 ENSP00000451568 ENST00000556298	G3V437 [Direct mapping] Protein angel homolog 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		129 aa 14.1 kDa	No	0
ANGEL1-005 ENSP00000451534 ENST00000557179	G3V414 [Direct mapping] Protein angel homolog 1 Show all	Phobius predicted secreted proteins Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		235 aa 26.6 kDa	No	0
ANGEL1-007 ENSP00000452287 ENST00000555079	G3V5C4 [Direct mapping] Protein angel homolog 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		67 aa 7.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.