Expression of GPRC5A in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

GPRC5A

TISSUE

premium

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	GPRC5A
Gene description	G protein-coupled receptor, class C, group 5, member A
Protein class	G-protein coupled receptors Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	3
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (CAPAN-2, SiHa)
HPA (normal tissue):	Tissue enhanced (lung)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, most abundant in lung.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA007928
	SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable) and renal cancer (unfavourable).
Pancreatic cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

Pancreatic cancer

STAINING SUMMARY

HPA007928

GENE INFORMATION
Gene name	GPRC5A (HGNC Symbol)
Synonyms	PEIG-1, RAI3, RAIG1, TIG1
Description	G protein-coupled receptor, class C, group 5, member A (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the type 3 G protein-coupling receptor family, characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction between retinoid acid and G protein signalling pathways. Retinoic acid plays a critical role in development, cellular growth, and differentiation. This gene may play a role in embryonic development and epithelial cell differentiation. [provided by RefSeq, Jul 2008]
Chromosome	12
Cytoband	p13.1
Chromosome location (bp)	12890782 - 12917937
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000013588 (version 83.38)
Entrez gene	9052
UniProt	Q8NFJ5 (UniProt - Evidence at protein level)
neXtProt	NX_Q8NFJ5
Antibodypedia	GPRC5A antibodies

PROTEIN BROWSER

GPRC5A-001	GPRC5A-004	GPRC5A-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
GPRC5A-001 ENSP00000014914 ENST00000014914	Q8NFJ5 [Direct mapping] Retinoic acid-induced protein 3 Show all	Family 3 (C) receptors G-protein coupled receptors GPCRs excl olfactory receptors Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0007165 [signal transduction] GO:0007175 [negative regulation of epidermal growth factor-activated receptor activity] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0030659 [cytoplasmic vesicle membrane] GO:0043231 [intracellular membrane-bounded organelle] GO:0070062 [extracellular exosome] Show all	357 aa 40.3 kDa	No	7
GPRC5A-004 ENSP00000441627 ENST00000534831	F5GWG3 [Direct mapping] Retinoic acid-induced protein 3 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins GPCRHMM predicted membrane proteins # TM segments-based 7TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004930 [G-protein coupled receptor activity] GO:0005886 [plasma membrane] GO:0007186 [G-protein coupled receptor signaling pathway] GO:0016021 [integral component of membrane] GO:0043231 [intracellular membrane-bounded organelle] Show all	274 aa 30.6 kDa	No	7
GPRC5A-005 ENSP00000439430 ENST00000540125	H0YFN2 [Direct mapping] Retinoic acid-induced protein 3 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		66 aa 7.7 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.