Expression of CD6 in cancer - Summary - The Human Protein Atlas

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CD6

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CD6
Gene description	CD6 molecule
Protein class	CD markers Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enriched (MOLT-4)
HPA (normal tissue):	Tissue enhanced (appendix, lymph node)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Highly selective cytoplasmic expression was observed in immune cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. CAB002489 , CAB016252
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PROGNOSTIC SUMMARY
Prognostic marker in head and neck cancer (favourable), cervical cancer (favourable), renal cancer (unfavourable), breast cancer (favourable) and endometrial cancer (favourable).
Head and neck cancer p<0.001 Cervical cancer p<0.001 Renal cancer p<0.001 Breast cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

CAB002489	CAB016252

GENE INFORMATION
Gene name	CD6 (HGNC Symbol)
Synonyms	Tp120
Description	CD6 molecule (HGNC Symbol)
Entrez gene summary	This gene encodes a protein found on the outer membrane of T-lymphocytes as well as some other immune cells. The encoded protein contains three scavenger receptor cysteine-rich (SRCR) domains and a binding site for an activated leukocyte cell adhesion molecule. The gene product is important for continuation of T cell activation. This gene may be associated with susceptibility to multiple sclerosis (PMID: 19525953, 21849685). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Chromosome	11
Cytoband	q12.2
Chromosome location (bp)	60971680 - 61020377
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000013725 (version 83.38)
Entrez gene	923
UniProt	P30203 (UniProt - Evidence at protein level)
neXtProt	NX_P30203
Antibodypedia	CD6 antibodies

PROTEIN BROWSER

CD6-001	CD6-005	CD6-006	CD6-007	CD6-008	CD6-013

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CD6-001 ENSP00000323280 ENST00000313421	P30203 [Direct mapping] T-cell differentiation antigen CD6 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005044 [scavenger receptor activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0006898 [receptor-mediated endocytosis] GO:0007155 [cell adhesion] GO:0016020 [membrane] Show all	668 aa 71.8 kDa	Yes	1
CD6-005 ENSP00000440055 ENST00000542157	F6UFK6 [Direct mapping] T-cell differentiation antigen CD6 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005044 [scavenger receptor activity] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] Show all	278 aa 29.2 kDa	Yes	0
CD6-006 ENSP00000410638 ENST00000433107	E7ER04 [Direct mapping] T-cell differentiation antigen CD6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005044 [scavenger receptor activity] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	422 aa 45 kDa	Yes	1
CD6-007 ENSP00000390676 ENST00000452451	P30203 [Direct mapping] T-cell differentiation antigen CD6 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005044 [scavenger receptor activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0006898 [receptor-mediated endocytosis] GO:0007155 [cell adhesion] GO:0016020 [membrane] Show all	592 aa 63.6 kDa	Yes	1
CD6-008 ENSP00000340628 ENST00000352009	P30203 [Direct mapping] T-cell differentiation antigen CD6 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005044 [scavenger receptor activity] GO:0005515 [protein binding] GO:0005887 [integral component of plasma membrane] GO:0006898 [receptor-mediated endocytosis] GO:0007155 [cell adhesion] GO:0016020 [membrane] Show all	601 aa 64.7 kDa	Yes	1
CD6-013 ENSP00000443747 ENST00000538611	H0YGL3 [Direct mapping] T-cell differentiation antigen CD6 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0005044 [scavenger receptor activity] GO:0006898 [receptor-mediated endocytosis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] Show all	186 aa 20 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.