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CAPN1

GENERAL INFORMATION

Gene name

 CAPN1

Gene description

 Calpain 1, (mu/I) large subunit

Protein class

 Enzymes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 15
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Expressed in all
GTEx:Expressed in all
FANTOM5:Expressed in all

Protein evidence

 Evidence at protein level

Protein expression

 Ubiquitous cytoplasmic expression.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA005992
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Expressed in all

GENE INFORMATION

Gene name

 CAPN1 (HGNC Symbol)

Synonyms

 CANP, CANPL1, muCANP, muCL

Description

 Calpain 1, (mu/I) large subunit (HGNC Symbol)

Entrez gene summary

 The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]

Chromosome

 11

Cytoband

 q13.1

Chromosome location (bp)

 65180566 - 65212006

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000014216 (version 83.38)

Entrez gene

 823

UniProt

 P07384 (UniProt - Evidence at protein level)

neXtProt

 NX_P07384

Antibodypedia

 CAPN1 antibodies

PROTEIN BROWSER
«
CAPN1-001
CAPN1-002
CAPN1-003
CAPN1-004
CAPN1-009
CAPN1-010
CAPN1-011
CAPN1-012
CAPN1-013
CAPN1-015
CAPN1-017
CAPN1-026
CAPN1-027
CAPN1-028
CAPN1-029
»

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CAPN1-001
ENSP00000435272
ENST00000533820
P07384 [Direct mapping]
Calpain-1 catalytic subunit
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006508 [proteolysis]
GO:0008284 [positive regulation of cell proliferation]
GO:0016020 [membrane]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0070062 [extracellular exosome]
Show all
 714 aa
81.9 kDa 		No 0
CAPN1-002
ENSP00000434176
ENST00000524773
P07384 [Direct mapping]
Calpain-1 catalytic subunit
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006508 [proteolysis]
GO:0008284 [positive regulation of cell proliferation]
GO:0016020 [membrane]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0070062 [extracellular exosome]
Show all
 714 aa
81.9 kDa 		No 0
CAPN1-003
ENSP00000279247
ENST00000279247
P07384 [Direct mapping]
Calpain-1 catalytic subunit
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006508 [proteolysis]
GO:0008284 [positive regulation of cell proliferation]
GO:0016020 [membrane]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0070062 [extracellular exosome]
Show all
 714 aa
81.9 kDa 		No 0
CAPN1-004
ENSP00000431984
ENST00000527323
P07384 [Direct mapping]
Calpain-1 catalytic subunit
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005739 [mitochondrion]
GO:0005764 [lysosome]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006508 [proteolysis]
GO:0008092 [cytoskeletal protein binding]
GO:0008284 [positive regulation of cell proliferation]
GO:0016020 [membrane]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0032801 [receptor catabolic process]
GO:0060056 [mammary gland involution]
GO:0070062 [extracellular exosome]
Show all
 714 aa
81.9 kDa 		No 0
CAPN1-009
ENSP00000433823
ENST00000527739
E9PJA6 [Direct mapping]
Calpain-1 catalytic subunit
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005622 [intracellular]
GO:0006508 [proteolysis]
Show all
 162 aa
18.2 kDa 		No 0
CAPN1-010
ENSP00000431793
ENST00000534373
E9PJJ3 [Direct mapping]
Calpain-1 catalytic subunit
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005622 [intracellular]
GO:0006508 [proteolysis]
Show all
 136 aa
15.1 kDa 		No 0
CAPN1-011
ENSP00000436693
ENST00000532285
E9PIA9 [Direct mapping]
Calpain-1 catalytic subunit
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0006508 [proteolysis]
Show all
 63 aa
7.2 kDa 		No 0
CAPN1-012
ENSP00000435092
ENST00000531068
E9PLX0 [Direct mapping]
Calpain-1 catalytic subunit
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005622 [intracellular]
GO:0006508 [proteolysis]
Show all
 122 aa
13.6 kDa 		No 0
CAPN1-013
ENSP00000431172
ENST00000527699
E9PMC6 [Direct mapping]
Calpain-1 catalytic subunit
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005622 [intracellular]
GO:0006508 [proteolysis]
Show all
 152 aa
16.9 kDa 		No 0
CAPN1-015
ENSP00000433366
ENST00000526468
E9PL37 [Direct mapping]
Calpain-1 catalytic subunit
Show all
   SPOCTOPUS predicted secreted proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005622 [intracellular]
GO:0006508 [proteolysis]
Show all
 191 aa
21.1 kDa 		No 0
CAPN1-017
ENSP00000431528
ENST00000526966
E9PJA6 [Direct mapping]
Calpain-1 catalytic subunit
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005622 [intracellular]
GO:0006508 [proteolysis]
Show all
 162 aa
18.2 kDa 		No 0
CAPN1-026
ENSP00000435847
ENST00000528396
E9PSA6 [Direct mapping]
Calpain-1 catalytic subunit
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005622 [intracellular]
GO:0006508 [proteolysis]
Show all
 163 aa
18.3 kDa 		No 0
CAPN1-027
ENSP00000432512
ENST00000529133
E9PQB3 [Direct mapping]
Calpain-1 catalytic subunit
Show all
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005622 [intracellular]
GO:0006508 [proteolysis]
Show all
 191 aa
21.4 kDa 		No 0
CAPN1-028
ENSP00000431686
ENST00000533129
P07384 [Direct mapping]
Calpain-1 catalytic subunit
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   Peptidases
   Cysteine-type peptidases
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Plasma proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005515 [protein binding]
GO:0005622 [intracellular]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0005886 [plasma membrane]
GO:0005925 [focal adhesion]
GO:0006508 [proteolysis]
GO:0008284 [positive regulation of cell proliferation]
GO:0016020 [membrane]
GO:0022617 [extracellular matrix disassembly]
GO:0030198 [extracellular matrix organization]
GO:0070062 [extracellular exosome]
Show all
 714 aa
81.9 kDa 		No 0
CAPN1-029
ENSP00000435198
ENST00000533909
E9PLC9 [Direct mapping]
Calpain-1 catalytic subunit
Show all
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004198 [calcium-dependent cysteine-type endopeptidase activity]
GO:0005509 [calcium ion binding]
GO:0005622 [intracellular]
GO:0006508 [proteolysis]
Show all
 148 aa
16.4 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.