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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

ACPP

Gene description

Acid phosphatase, prostate

Protein class

Cancer-related genes
Enzymes
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

Intracellular,Membrane,Secreted

Number of transcripts

5
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Tissue enriched (prostate cancer)
HPA (cell line):Cell line enhanced (RPMI-8226)
HPA (normal tissue):Tissue enriched (prostate)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in prostate.

ANTIBODY IHC RELIABILITY

Data reliability
description

Antibody staining consistent with RNA expression data.

Reliability score

Supported based on 3 antibodies.
HPA004335 , HPA063916 , CAB000071
SHOW MORE

PROGNOSTIC SUMMARY

Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Tissue enriched (prostate cancer)

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY

HPA004335
HPA063916
CAB000071

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Strong cytoplasmic immunoreactivity was observed in prostate carcinomas. Few ovarian-, pancreatic- and colo-rectal cancers had minimal cytoplasmic staining in a small fraction of the cells. Remaining cancers were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

Prostate cancers exhibited moderate to strong cytoplasmic positivity. A rare case of adenocarcinoma of colon displayed moderate membranous staining. Remaining cancer tissues were negative.

Cancer

Cancer staining

Protein
expression of
normal tissue

Breast cancer
 
Carcinoid
 
Cervical cancer
 
 
Colorectal cancer
 
 
Endometrial cancer
 
 
Glioma
 
Head and neck cancer
 
 
Liver cancer
 
 
Lung cancer
 
 
Lymphoma
 
 
 

Cancer

Cancer staining

Protein
expression of
normal tissue

Melanoma
 
Ovarian cancer
 
Pancreatic cancer
 
Prostate cancer
 
Renal cancer
 
Skin cancer
 
Stomach cancer
 
 
Testis cancer
 
Thyroid cancer
 
Urothelial cancer
 

Staining summary

All prostate cancers displayed strong cytoplasmic immunoreactivity. Remaining cancers were negative.

GENE INFORMATION

Gene name

ACPP (HGNC Symbol)

Synonyms

ACP-3, ACP3, PAP

Description

Acid phosphatase, prostate (HGNC Symbol)

Entrez gene summary

This gene encodes an enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. An alternatively spliced transcript variant encoding a longer isoform has been found for this gene. This isoform contains a transmembrane domain and is localized in the plasma membrane-endosomal-lysosomal pathway. [provided by RefSeq, Sep 2008]

Chromosome

3

Cytoband

q22.1

Chromosome location (bp)

132317367 - 132368298

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000014257 (version 83.38)

Entrez gene

55

UniProt

P15309 (UniProt - Evidence at protein level)

neXtProt

NX_P15309

Antibodypedia

ACPP antibodies

PROTEIN BROWSER

ACPP-001
ACPP-002
ACPP-003
ACPP-004
ACPP-009

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

ACPP-001
ENSP00000337471
ENST00000336375
P15309 [Direct mapping]
Prostatic acid phosphatase PAPf39
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003993 [acid phosphatase activity]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005765 [lysosomal membrane]
GO:0005886 [plasma membrane]
GO:0006772 [thiamine metabolic process]
GO:0008253 [5'-nucleotidase activity]
GO:0012506 [vesicle membrane]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0042131 [thiamine phosphate phosphatase activity]
GO:0042802 [identical protein binding]
GO:0046085 [adenosine metabolic process]
GO:0051930 [regulation of sensory perception of pain]
GO:0052642 [lysophosphatidic acid phosphatase activity]
GO:0060168 [positive regulation of adenosine receptor signaling pathway]
GO:0070062 [extracellular exosome]
Show all
386 aa
44.6 kDa
Yes 0
ACPP-002
ENSP00000417744
ENST00000475741
P15309 [Direct mapping]
Prostatic acid phosphatase PAPf39
Show all
Enzymes
   ENZYME proteins
   Hydrolases
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003993 [acid phosphatase activity]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005765 [lysosomal membrane]
GO:0005886 [plasma membrane]
GO:0006772 [thiamine metabolic process]
GO:0008253 [5'-nucleotidase activity]
GO:0012506 [vesicle membrane]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0042131 [thiamine phosphate phosphatase activity]
GO:0042802 [identical protein binding]
GO:0046085 [adenosine metabolic process]
GO:0051930 [regulation of sensory perception of pain]
GO:0052642 [lysophosphatidic acid phosphatase activity]
GO:0060168 [positive regulation of adenosine receptor signaling pathway]
GO:0070062 [extracellular exosome]
Show all
353 aa
40.4 kDa
Yes 0
ACPP-003
ENSP00000323036
ENST00000351273
P15309 [Direct mapping]
Prostatic acid phosphatase PAPf39
Show all
Enzymes
   ENZYME proteins
   Hydrolases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003993 [acid phosphatase activity]
GO:0005615 [extracellular space]
GO:0005622 [intracellular]
GO:0005634 [nucleus]
GO:0005765 [lysosomal membrane]
GO:0005771 [multivesicular body]
GO:0005886 [plasma membrane]
GO:0006144 [purine nucleobase metabolic process]
GO:0006772 [thiamine metabolic process]
GO:0008253 [5'-nucleotidase activity]
GO:0009117 [nucleotide metabolic process]
GO:0012506 [vesicle membrane]
GO:0016021 [integral component of membrane]
GO:0016311 [dephosphorylation]
GO:0016791 [phosphatase activity]
GO:0030141 [secretory granule]
GO:0030175 [filopodium]
GO:0031985 [Golgi cisterna]
GO:0033265 [choline binding]
GO:0042131 [thiamine phosphate phosphatase activity]
GO:0042802 [identical protein binding]
GO:0045177 [apical part of cell]
GO:0046085 [adenosine metabolic process]
GO:0051930 [regulation of sensory perception of pain]
GO:0052642 [lysophosphatidic acid phosphatase activity]
GO:0060168 [positive regulation of adenosine receptor signaling pathway]
GO:0070062 [extracellular exosome]
Show all
418 aa
48.3 kDa
Yes 1
ACPP-004
ENSP00000418366
ENST00000495911
E9PFE6 [Direct mapping]
Prostatic acid phosphatase
Show all
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0003993 [acid phosphatase activity]
GO:0016311 [dephosphorylation]
Show all
165 aa
19 kDa
Yes 0
ACPP-009
ENSP00000422036
ENST00000507647
H0Y8T3 [Direct mapping]
Prostatic acid phosphatase
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
99 aa
11.3 kDa
No 0

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The Human Protein Atlas project is funded
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