Expression of ACPP in cancer - Summary - The Human Protein Atlas

We use cookies to enhance the usability of our website. If you continue, we'll assume that you are happy to receive all cookies. More information. Don't show this again.

ACPP

premium

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	ACPP
Gene description	Acid phosphatase, prostate
Protein class	Cancer-related genes Enzymes Plasma proteins Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	5
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (prostate cancer)
HPA (cell line):	Cell line enhanced (RPMI-8226)
HPA (normal tissue):	Tissue enriched (prostate)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Selective cytoplasmic expression in prostate.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining consistent with RNA expression data.
Reliability score	Supported based on 3 antibodies. HPA004335 , HPA063916 , CAB000071
	SHOW MORE

PROGNOSTIC SUMMARY
Gene product is not prognostic.
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (prostate cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA004335	HPA063916	CAB000071

GENE INFORMATION
Gene name	ACPP (HGNC Symbol)
Synonyms	ACP-3, ACP3, PAP
Description	Acid phosphatase, prostate (HGNC Symbol)
Entrez gene summary	This gene encodes an enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. An alternatively spliced transcript variant encoding a longer isoform has been found for this gene. This isoform contains a transmembrane domain and is localized in the plasma membrane-endosomal-lysosomal pathway. [provided by RefSeq, Sep 2008]
Chromosome	3
Cytoband	q22.1
Chromosome location (bp)	132317367 - 132368298
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000014257 (version 83.38)
Entrez gene	55
UniProt	P15309 (UniProt - Evidence at protein level)
neXtProt	NX_P15309
Antibodypedia	ACPP antibodies

PROTEIN BROWSER

ACPP-001	ACPP-002	ACPP-003	ACPP-004	ACPP-009

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
ACPP-001 ENSP00000337471 ENST00000336375	P15309 [Direct mapping] Prostatic acid phosphatase PAPf39 Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003993 [acid phosphatase activity] GO:0005615 [extracellular space] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005765 [lysosomal membrane] GO:0005886 [plasma membrane] GO:0006772 [thiamine metabolic process] GO:0008253 [5'-nucleotidase activity] GO:0012506 [vesicle membrane] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0042131 [thiamine phosphate phosphatase activity] GO:0042802 [identical protein binding] GO:0046085 [adenosine metabolic process] GO:0051930 [regulation of sensory perception of pain] GO:0052642 [lysophosphatidic acid phosphatase activity] GO:0060168 [positive regulation of adenosine receptor signaling pathway] GO:0070062 [extracellular exosome] Show all	386 aa 44.6 kDa	Yes	0
ACPP-002 ENSP00000417744 ENST00000475741	P15309 [Direct mapping] Prostatic acid phosphatase PAPf39 Show all	Enzymes ENZYME proteins Hydrolases MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Ezkurdia et al 2014) Show all	GO:0003993 [acid phosphatase activity] GO:0005615 [extracellular space] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005765 [lysosomal membrane] GO:0005886 [plasma membrane] GO:0006772 [thiamine metabolic process] GO:0008253 [5'-nucleotidase activity] GO:0012506 [vesicle membrane] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0042131 [thiamine phosphate phosphatase activity] GO:0042802 [identical protein binding] GO:0046085 [adenosine metabolic process] GO:0051930 [regulation of sensory perception of pain] GO:0052642 [lysophosphatidic acid phosphatase activity] GO:0060168 [positive regulation of adenosine receptor signaling pathway] GO:0070062 [extracellular exosome] Show all	353 aa 40.4 kDa	Yes	0
ACPP-003 ENSP00000323036 ENST00000351273	P15309 [Direct mapping] Prostatic acid phosphatase PAPf39 Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Cancer-related genes Candidate cancer biomarkers Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003993 [acid phosphatase activity] GO:0005615 [extracellular space] GO:0005622 [intracellular] GO:0005634 [nucleus] GO:0005765 [lysosomal membrane] GO:0005771 [multivesicular body] GO:0005886 [plasma membrane] GO:0006144 [purine nucleobase metabolic process] GO:0006772 [thiamine metabolic process] GO:0008253 [5'-nucleotidase activity] GO:0009117 [nucleotide metabolic process] GO:0012506 [vesicle membrane] GO:0016021 [integral component of membrane] GO:0016311 [dephosphorylation] GO:0016791 [phosphatase activity] GO:0030141 [secretory granule] GO:0030175 [filopodium] GO:0031985 [Golgi cisterna] GO:0033265 [choline binding] GO:0042131 [thiamine phosphate phosphatase activity] GO:0042802 [identical protein binding] GO:0045177 [apical part of cell] GO:0046085 [adenosine metabolic process] GO:0051930 [regulation of sensory perception of pain] GO:0052642 [lysophosphatidic acid phosphatase activity] GO:0060168 [positive regulation of adenosine receptor signaling pathway] GO:0070062 [extracellular exosome] Show all	418 aa 48.3 kDa	Yes	1
ACPP-004 ENSP00000418366 ENST00000495911	E9PFE6 [Direct mapping] Prostatic acid phosphatase Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003993 [acid phosphatase activity] GO:0016311 [dephosphorylation] Show all	165 aa 19 kDa	Yes	0
ACPP-009 ENSP00000422036 ENST00000507647	H0Y8T3 [Direct mapping] Prostatic acid phosphatase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		99 aa 11.3 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.