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COX15

GENERAL INFORMATION

Gene name

 COX15

Gene description

 Cytochrome c oxidase assembly homolog 15 (yeast)

Protein class

 Disease related genes
Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Pending external verification.

Reliability score

 Uncertain based on 2 antibodies.
HPA037727 , HPA037728
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA037727
HPA037728

GENE INFORMATION

Gene name

 COX15 (HGNC Symbol)

Synonyms

 CEMCOX2

Description

 Cytochrome c oxidase assembly homolog 15 (yeast) (HGNC Symbol)

Entrez gene summary

 Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein which is not a structural subunit, but may be essential for the biogenesis of COX formation and may function in the hydroxylation of heme O, according to the yeast mutant studies. This protein is predicted to contain 5 transmembrane domains localized in the mitochondrial inner membrane. Alternative splicing of this gene generates two transcript variants diverging in the 3' region. [provided by RefSeq, Jul 2008]

Chromosome

 10

Cytoband

 q24.2

Chromosome location (bp)

 99711844 - 99732100

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000014919 (version 83.38)

Entrez gene

 1355

UniProt

 Q7KZN9 (UniProt - Evidence at protein level)

neXtProt

 NX_Q7KZN9

Antibodypedia

 COX15 antibodies

PROTEIN BROWSER
COX15-001
COX15-002

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
COX15-001
ENSP00000016171
ENST00000016171
Q7KZN9 [Direct mapping]
Cytochrome c oxidase assembly protein COX15 homolog
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   8TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004129 [cytochrome-c oxidase activity]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005746 [mitochondrial respiratory chain]
GO:0006123 [mitochondrial electron transport, cytochrome c to oxygen]
GO:0006778 [porphyrin-containing compound metabolic process]
GO:0006783 [heme biosynthetic process]
GO:0006784 [heme a biosynthetic process]
GO:0007585 [respiratory gaseous exchange]
GO:0008535 [respiratory chain complex IV assembly]
GO:0016021 [integral component of membrane]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0016653 [oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor]
GO:0044281 [small molecule metabolic process]
GO:0045333 [cellular respiration]
GO:0055114 [oxidation-reduction process]
GO:0070069 [cytochrome complex]
GO:1902600 [hydrogen ion transmembrane transport]
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 410 aa
46 kDa 		No 8
COX15-002
ENSP00000359514
ENST00000370483
Q7KZN9 [Direct mapping]
Cytochrome c oxidase assembly protein COX15 homolog
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   7TM proteins predicted by MDM
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004129 [cytochrome-c oxidase activity]
GO:0005739 [mitochondrion]
GO:0005743 [mitochondrial inner membrane]
GO:0005746 [mitochondrial respiratory chain]
GO:0006123 [mitochondrial electron transport, cytochrome c to oxygen]
GO:0006778 [porphyrin-containing compound metabolic process]
GO:0006783 [heme biosynthetic process]
GO:0006784 [heme a biosynthetic process]
GO:0007585 [respiratory gaseous exchange]
GO:0008535 [respiratory chain complex IV assembly]
GO:0016021 [integral component of membrane]
GO:0016627 [oxidoreductase activity, acting on the CH-CH group of donors]
GO:0016653 [oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor]
GO:0044281 [small molecule metabolic process]
GO:0045333 [cellular respiration]
GO:0055114 [oxidation-reduction process]
GO:0070069 [cytochrome complex]
GO:1902600 [hydrogen ion transmembrane transport]
Show all
 388 aa
43.8 kDa 		No 7

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.