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CCDC88C

GENERAL INFORMATION

Gene name

 CCDC88C

Gene description

 Coiled-coil domain containing 88C

Protein class

 Disease related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Cell line enhanced (SCLC-21H, U-266/84)
HPA (normal tissue):Mixed

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 1 antibody.
HPA005832
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), lung cancer (favourable) and head and neck cancer (favourable).
Renal cancer p<0.001
Lung cancer p<0.001
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA005832

GENE INFORMATION

Gene name

 CCDC88C (HGNC Symbol)

Synonyms

 DAPLE, HkRP2, KIAA1509, SCA40

Description

 Coiled-coil domain containing 88C (HGNC Symbol)

Entrez gene summary

 This gene encodes a ubiquitously expressed coiled-coil domain-containing protein that interacts with the dishevelled protein and is a negative regulator of the Wnt signalling pathway. The protein encoded by this gene has a PDZ-domain binding motif in its C-terminus with which it interacts with the dishevelled protein. Dishevelled is a scaffold protein involved in the regulation of the Wnt signaling pathway. The Wnt signaling pathway plays an important role in embryonic development, tissue maintenance, and cancer progression. Mutations in this gene cause autosomal recessive, primary non-syndromic congenital hydrocephalus; a condition characterized by excessive accumulation of cerebrospinal fluid in the ventricles of the brain. [provided by RefSeq, Jan 2013]

Chromosome

 14

Cytoband

Chromosome location (bp)

 91271323 - 91417844

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000015133 (version 83.38)

Entrez gene

 440193

UniProt

 Q9P219 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9P219

Antibodypedia

 CCDC88C antibodies

PROTEIN BROWSER
CCDC88C-001
CCDC88C-002
CCDC88C-003
CCDC88C-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CCDC88C-001
ENSP00000374507
ENST00000389857
Q9P219 [Direct mapping]
Protein Daple
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Predicted intracellular proteins
Plasma proteins
Disease related genes
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0001932 [regulation of protein phosphorylation]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0016055 [Wnt signaling pathway]
GO:0030165 [PDZ domain binding]
GO:0031098 [stress-activated protein kinase signaling cascade]
GO:0031648 [protein destabilization]
GO:0043621 [protein self-association]
GO:0051260 [protein homooligomerization]
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 2028 aa
228.2 kDa 		No 0
CCDC88C-002
ENSP00000451392
ENST00000553403
G3V3S0 [Direct mapping]
Protein Daple
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0016055 [Wnt signaling pathway]
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 96 aa
11.3 kDa 		No 0
CCDC88C-003
ENSP00000374506
ENST00000389856
Q0P665 [Direct mapping]
CCDC88C protein; Protein Daple
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0016055 [Wnt signaling pathway]
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 88 aa
10.2 kDa 		No 0
CCDC88C-201
ENSP00000330332
ENST00000331194
A0A0A0MR69 [Direct mapping]
Protein Daple
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0016055 [Wnt signaling pathway]
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 506 aa
52.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.