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Fractions of tumor cells in a few hepatocellular carcinomas and renal cell carcinomas showed moderate to strong nuclear positivity. Other cancer tissues were negative.
GENE INFORMATION
Gene name
ISL1 (HGNC Symbol)
Synonyms
Isl-1, ISLET1
Description
ISL LIM homeobox 1 (HGNC Symbol)
Entrez gene summary
This gene encodes a member of the LIM/homeodomain family of transcription factors. The encoded protein binds to the enhancer region of the insulin gene, among others, and may play an important role in regulating insulin gene expression. The encoded protein is central to the development of pancreatic cell lineages and may also be required for motor neuron generation. Mutations in this gene have been associated with maturity-onset diabetes of the young. [provided by RefSeq, Jul 2008]