Expression of IL20RA in cancer - Summary - The Human Protein Atlas

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IL20RA

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	IL20RA
Gene description	Interleukin 20 receptor, alpha
Protein class	Predicted intracellular proteins Predicted membrane proteins Predicted secreted proteins
Predicted localization	Intracellular,Membrane,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Group enriched (CAPAN-2, HaCaT, RT4, SH-SY5Y, T-47d)
HPA (normal tissue):	Tissue enhanced (skin)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA042281 , CAB024990
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PROGNOSTIC SUMMARY
Prognostic marker in endometrial cancer (favourable) and head and neck cancer (favourable).
Endometrial cancer p<0.001 Head and neck cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA042281	CAB024990

GENE INFORMATION
Gene name	IL20RA (HGNC Symbol)
Synonyms	IL-20R1, ZCYTOR7
Description	Interleukin 20 receptor, alpha (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the type II cytokine receptor family. The encoded protein is a subunit of the receptor for interleukin 20, a cytokine that may be involved in epidermal function. The interleukin 20 receptor is a heterodimeric complex consisting of the encoded protein and interleukin 20 receptor beta. This gene and interleukin 20 receptor beta are highly expressed in skin, and are upregulated in psoriasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Chromosome	6
Cytoband	q23.3
Chromosome location (bp)	136999971 - 137045180
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000016402 (version 83.38)
Entrez gene	53832
UniProt	Q9UHF4 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UHF4
Antibodypedia	IL20RA antibodies

PROTEIN BROWSER

IL20RA-001	IL20RA-002	IL20RA-003	IL20RA-006	IL20RA-201	IL20RA-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
IL20RA-001 ENSP00000314976 ENST00000316649	Q9UHF4 [Direct mapping] Interleukin-20 receptor subunit alpha Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0042015 [interleukin-20 binding] GO:0045124 [regulation of bone resorption] GO:2001244 [positive regulation of intrinsic apoptotic signaling pathway] Show all	553 aa 62.5 kDa	Yes	1
IL20RA-002 ENSP00000489177 ENST00000468393		Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005515 [protein binding] Show all	177 aa 20.3 kDa	No	1
IL20RA-003 ENSP00000356720 ENST00000367746	Q96SH7 [Direct mapping] Interleukin 20 receptor, alpha, isoform CRA_b; Interleukin-20 receptor subunit alpha Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Show all	GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0042015 [interleukin-20 binding] Show all	209 aa 23.6 kDa	Yes	0
IL20RA-006 ENSP00000489419 ENST00000635289		SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Show all	GO:0005515 [protein binding] Show all	89 aa 10.4 kDa	No	0
IL20RA-201 ENSP00000356722 ENST00000367748	Q9UHF4 [Direct mapping] Interleukin-20 receptor subunit alpha Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0042015 [interleukin-20 binding] Show all	442 aa 49.9 kDa	No	1
IL20RA-202 ENSP00000437843 ENST00000541547	Q9UHF4 [Direct mapping] Interleukin-20 receptor subunit alpha Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0004896 [cytokine receptor activity] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0019221 [cytokine-mediated signaling pathway] GO:0042015 [interleukin-20 binding] Show all	504 aa 57.4 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.