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CLCA1

GENERAL INFORMATION

Gene name

 CLCA1

Gene description

 Chloride channel accessory 1

Protein class

 Predicted secreted proteins
Transporters

Predicted localization

 Secreted

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Group enriched (colorectal cancer, pancreatic cancer)
HPA (cell line):Cell line enhanced (BEWO, NB-4, RPMI-8226, SH-SY5Y, U-2197)
HPA (normal tissue):Group enriched (colon, duodenum, rectum, small intestine)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Selective cytoplasmic expression in intestinal goblet cells.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 2 antibodies.
HPA052787 , HPA059301
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (favourable).
Colorectal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Group enriched (colorectal cancer, pancreatic cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Pancreatic cancer

STAINING SUMMARY
HPA052787
HPA059301

GENE INFORMATION

Gene name

 CLCA1 (HGNC Symbol)

Synonyms

 CaCC, CLCRG1

Description

 Chloride channel accessory 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p22.3

Chromosome location (bp)

 86468368 - 86500289

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000016490 (version 83.38)

Entrez gene

 1179

UniProt

 A8K7I4 (UniProt - Evidence at protein level)

neXtProt

 NX_A8K7I4

Antibodypedia

 CLCA1 antibodies

PROTEIN BROWSER
CLCA1-001
CLCA1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CLCA1-001
ENSP00000234701
ENST00000234701
A8K7I4 [Direct mapping]
Calcium-activated chloride channel regulator 1
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Transporters
   Transporter channels and pores
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005229 [intracellular calcium activated chloride channel activity]
GO:0005254 [chloride channel activity]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0005902 [microvillus]
GO:0006508 [proteolysis]
GO:0006810 [transport]
GO:0006816 [calcium ion transport]
GO:0006821 [chloride transport]
GO:0008237 [metallopeptidase activity]
GO:0016021 [integral component of membrane]
GO:0030141 [secretory granule]
GO:0034220 [ion transmembrane transport]
GO:0042589 [zymogen granule membrane]
GO:0046872 [metal ion binding]
GO:0055085 [transmembrane transport]
GO:0071456 [cellular response to hypoxia]
GO:1902476 [chloride transmembrane transport]
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 914 aa
100.2 kDa 		Yes 0
CLCA1-201
ENSP00000378200
ENST00000394711
A8K7I4 [Direct mapping]
Calcium-activated chloride channel regulator 1
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Transporters
   Transporter channels and pores
Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005229 [intracellular calcium activated chloride channel activity]
GO:0005254 [chloride channel activity]
GO:0005615 [extracellular space]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006508 [proteolysis]
GO:0006810 [transport]
GO:0006816 [calcium ion transport]
GO:0006821 [chloride transport]
GO:0008237 [metallopeptidase activity]
GO:0034220 [ion transmembrane transport]
GO:0046872 [metal ion binding]
GO:0055085 [transmembrane transport]
GO:1902476 [chloride transmembrane transport]
Show all
 914 aa
100.2 kDa 		Yes 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.