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CLCA4

GENERAL INFORMATION

Gene name

 CLCA4

Gene description

 Chloride channel accessory 4

Protein class

 Predicted membrane proteins

Predicted localization

 Membrane

Number of transcripts

 1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Tissue enhanced (cervical cancer)
HPA (cell line):Cell line enriched (RT4)
HPA (normal tissue):Group enriched (colon, esophagus, rectum)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Cytoplasmic and membranous expression in a several tissues

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly not consistent with RNA expression data.

Reliability score

 Uncertain based on 1 antibody.
HPA017045
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PROGNOSTIC SUMMARY
Prognostic marker in colorectal cancer (favourable) and head and neck cancer (favourable).
Colorectal cancer p<0.001
Head and neck cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Tissue enhanced (cervical cancer)

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA017045

GENE INFORMATION

Gene name

 CLCA4 (HGNC Symbol)

Synonyms

 CaCC2

Description

 Chloride channel accessory 4 (HGNC Symbol)

Entrez gene summary

 The protein encoded by this gene belongs to the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same site on chromosome 1p31-p22 and share high degrees of homology in size, sequence and predicted structure, but differ significantly in their tissue distributions. Alternative splicing results in multiple transcript variants, only one of which is thought to be protein coding. [provided by RefSeq, Dec 2008]

Chromosome

 1

Cytoband

 p22.3

Chromosome location (bp)

 86547078 - 86580754

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000016602 (version 83.38)

Entrez gene

 22802

UniProt

 Q14CN2 (UniProt - Evidence at protein level)

neXtProt

 NX_Q14CN2

Antibodypedia

 CLCA4 antibodies

PROTEIN BROWSER
CLCA4-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
CLCA4-001
ENSP00000359594
ENST00000370563
Q14CN2 [Direct mapping]
Calcium-activated chloride channel regulator 4 Calcium-activated chloride channel regulator 4, 110 kDa form Calcium-activated chloride channel regulator 4, 30 kDa form
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005229 [intracellular calcium activated chloride channel activity]
GO:0005254 [chloride channel activity]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006508 [proteolysis]
GO:0006810 [transport]
GO:0006821 [chloride transport]
GO:0008237 [metallopeptidase activity]
GO:0016324 [apical plasma membrane]
GO:0034220 [ion transmembrane transport]
GO:0046872 [metal ion binding]
GO:0055085 [transmembrane transport]
GO:0070062 [extracellular exosome]
GO:1902476 [chloride transmembrane transport]
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 919 aa
101.3 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.