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Extracellular deposits and cytoplasmic expression in several tissues.
ANTIBODY IHC RELIABILITY
Data reliability description
Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Antibody staining in cells/structures not annotated, view images.
Few cases of colorectal, pancreatic, endometrial, squamous cell carcinomas and cholangiocarcinomas showed moderate membranous and occasional cytoplasmic positivity. Remaining cancer tissues were weakly stained or negative.
GENE INFORMATION
Gene name
IGF1 (HGNC Symbol)
Synonyms
IGF-I, IGF1A, IGFI
Description
Insulin-like growth factor 1 (somatomedin C) (HGNC Symbol)
Entrez gene summary
The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]