Expression of SLC38A5 in cancer - Summary - The Human Protein Atlas

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SLC38A5

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SLC38A5
Gene description	Solute carrier family 38, member 5
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	10
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (HeLa, Karpas-707, RPMI-8226)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Membranous and cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. External characterization data supports antibody staining.
Reliability score	Approved based on 1 antibody. HPA047411
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and pancreatic cancer (unfavourable).
Renal cancer p<0.001 Pancreatic cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA047411

GENE INFORMATION
Gene name	SLC38A5 (HGNC Symbol)
Synonyms	JM24, SN2
Description	Solute carrier family 38, member 5 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a system N sodium-coupled amino acid transporter. The encoded protein transports glutamine, asparagine, histidine, serine, alanine, and glycine across the cell membrane, but does not transport charged amino acids, imino acids, or N-alkylated amino acids. Alternative splicing results in multiple transcript variants, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Aug 2013]
Chromosome	X
Cytoband	p11.23
Chromosome location (bp)	48458537 - 48470256
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000017483 (version 83.38)
Entrez gene	92745
UniProt	Q8WUX1 (UniProt - Evidence at protein level)
neXtProt	NX_Q8WUX1
Antibodypedia	SLC38A5 antibodies

PROTEIN BROWSER

SLC38A5-001	SLC38A5-002	SLC38A5-003	SLC38A5-004	SLC38A5-007	SLC38A5-009	SLC38A5-011	SLC38A5-012	SLC38A5-201	SLC38A5-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC38A5-001 ENSP00000389644 ENST00000416711	C9JMY2 [Direct mapping] Sodium-coupled neutral amino acid transporter 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003333 [amino acid transmembrane transport] GO:0005887 [integral component of plasma membrane] GO:0015187 [glycine transmembrane transporter activity] GO:0015816 [glycine transport] Show all	191 aa 20.5 kDa	No	4
SLC38A5-002 ENSP00000407258 ENST00000441948	C9JWG4 [Direct mapping] Sodium-coupled neutral amino acid transporter 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003333 [amino acid transmembrane transport] GO:0005887 [integral component of plasma membrane] GO:0015187 [glycine transmembrane transporter activity] GO:0015816 [glycine transport] Show all	272 aa 29.3 kDa	No	5
SLC38A5-003 ENSP00000403976 ENST00000413668	C9JHH7 [Direct mapping] Sodium-coupled neutral amino acid transporter 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003333 [amino acid transmembrane transport] GO:0005887 [integral component of plasma membrane] GO:0015187 [glycine transmembrane transporter activity] GO:0015816 [glycine transport] Show all	219 aa 23.7 kDa	No	5
SLC38A5-004 ENSP00000402988 ENST00000440085	C9JNK4 [Direct mapping] Sodium-coupled neutral amino acid transporter 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 5TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003333 [amino acid transmembrane transport] GO:0005887 [integral component of plasma membrane] GO:0015187 [glycine transmembrane transporter activity] GO:0015816 [glycine transport] Show all	279 aa 30.1 kDa	No	5
SLC38A5-007 ENSP00000416948 ENST00000429543	C9JJU1 [Direct mapping] Sodium-coupled neutral amino acid transporter 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003333 [amino acid transmembrane transport] GO:0005887 [integral component of plasma membrane] GO:0015187 [glycine transmembrane transporter activity] GO:0015816 [glycine transport] Show all	164 aa 17.5 kDa	No	3
SLC38A5-009 ENSP00000483716 ENST00000488083	C9JJU1 [Direct mapping] Sodium-coupled neutral amino acid transporter 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003333 [amino acid transmembrane transport] GO:0005887 [integral component of plasma membrane] GO:0015187 [glycine transmembrane transporter activity] GO:0015816 [glycine transport] Show all	164 aa 17.5 kDa	No	3
SLC38A5-011 ENSP00000471683 ENST00000595796	Q8WUX1 [Direct mapping] Sodium-coupled neutral amino acid transporter 5 A0A024QYY0 [Target identity:100%; Query identity:100%] Solute carrier family 38, member 5, isoform CRA_a Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003333 [amino acid transmembrane transport] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006865 [amino acid transport] GO:0015187 [glycine transmembrane transporter activity] GO:0015816 [glycine transport] GO:0055085 [transmembrane transport] Show all	472 aa 51.5 kDa	No	>9
SLC38A5-012 ENSP00000478807 ENST00000619100	Q8WUX1 [Direct mapping] Sodium-coupled neutral amino acid transporter 5 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003333 [amino acid transmembrane transport] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006865 [amino acid transport] GO:0015187 [glycine transmembrane transporter activity] GO:0015816 [glycine transport] GO:0055085 [transmembrane transport] Show all	421 aa 45.9 kDa	No	>9
SLC38A5-201 ENSP00000481291 ENST00000620913	Q8WUX1 [Direct mapping] Sodium-coupled neutral amino acid transporter 5 A0A024QYY0 [Target identity:100%; Query identity:100%] Solute carrier family 38, member 5, isoform CRA_a Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003333 [amino acid transmembrane transport] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006811 [ion transport] GO:0006865 [amino acid transport] GO:0015187 [glycine transmembrane transporter activity] GO:0015816 [glycine transport] GO:0055085 [transmembrane transport] Show all	472 aa 51.5 kDa	No	>9
SLC38A5-202 ENSP00000484236 ENST00000622196	A0A087X1I6 [Direct mapping] Sodium-coupled neutral amino acid transporter 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 8TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0003333 [amino acid transmembrane transport] GO:0005887 [integral component of plasma membrane] GO:0015187 [glycine transmembrane transporter activity] GO:0015816 [glycine transport] Show all	403 aa 44.1 kDa	No	8

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The Human Protein Atlas

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