Expression of TTC27 in cancer - Summary - The Human Protein Atlas

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TTC27

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	TTC27
Gene description	Tetratricopeptide repeat domain 27
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	3
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly not consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA031246
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable) and renal cancer (unfavourable).
Liver cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA031246

GENE INFORMATION
Gene name	TTC27 (HGNC Symbol)
Synonyms	FLJ20272
Description	Tetratricopeptide repeat domain 27 (HGNC Symbol)
Entrez gene summary
Chromosome	2
Cytoband	p22.3
Chromosome location (bp)	32628032 - 32821051
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000018699 (version 83.38)
Entrez gene	55622
UniProt	Q6P3X3 (UniProt - Evidence at protein level)
neXtProt	NX_Q6P3X3
Antibodypedia	TTC27 antibodies

PROTEIN BROWSER

TTC27-001	TTC27-005	TTC27-006

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TTC27-001 ENSP00000313953 ENST00000317907	Q6P3X3 [Direct mapping] Tetratricopeptide repeat protein 27 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003674 [molecular_function] GO:0005515 [protein binding] GO:0005575 [cellular_component] GO:0008150 [biological_process] Show all	843 aa 96.6 kDa	No	0
TTC27-005 ENSP00000409230 ENST00000438654	H7C329 [Direct mapping] Tetratricopeptide repeat protein 27 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		71 aa 8.2 kDa	No	0
TTC27-006 ENSP00000393327 ENST00000448773	C9JVS4 [Direct mapping] Tetratricopeptide repeat protein 27 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		115 aa 13 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.