Expression of MARCO in cancer - Summary - The Human Protein Atlas

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MARCO

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	MARCO
Gene description	Macrophage receptor with collagenous structure
Protein class	Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Mixed
HPA (cell line):	Cell line enhanced (HaCaT, THP-1, U-2 OS, U-266/70)
HPA (normal tissue):	Tissue enhanced (appendix, lung)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in alveolar macrophages and Kupffer cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Antibody staining in cells/structures not annotated, view images.
Reliability score	Supported based on 1 antibody. HPA063793
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Mixed

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA063793

GENE INFORMATION
Gene name	MARCO (HGNC Symbol)
Synonyms	SCARA2
Description	Macrophage receptor with collagenous structure (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. The protein may bind both Gram-negative and Gram-positive bacteria via an extracellular, C-terminal, scavenger receptor cysteine-rich (SRCR) domain. In addition to short cytoplasmic and transmembrane domains, there is an extracellular spacer domain and a long, extracellular collagenous domain. The protein may form a trimeric molecule by the association of the collagenous domains of three identical polypeptide chains. [provided by RefSeq, Jul 2008]
Chromosome	2
Cytoband	q14.2
Chromosome location (bp)	118942166 - 118994660
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000019169 (version 83.38)
Entrez gene	8685
UniProt	Q9UEW3 (UniProt - Evidence at protein level)
neXtProt	NX_Q9UEW3
Antibodypedia	MARCO antibodies

PROTEIN BROWSER

MARCO-001	MARCO-003

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
MARCO-001 ENSP00000318916 ENST00000327097	Q9UEW3 [Direct mapping] Macrophage receptor MARCO Q4ZG40 [Target identity:100%; Query identity:100%] Macrophage receptor with collagenous structure; Putative uncharacterized protein MARCO; cDNA, FLJ93629, Homo sapiens macrophage receptor with collagenous structure(MARCO), mRNA Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002221 [pattern recognition receptor signaling pathway] GO:0004888 [transmembrane signaling receptor activity] GO:0005044 [scavenger receptor activity] GO:0005581 [collagen trimer] GO:0005886 [plasma membrane] GO:0005887 [integral component of plasma membrane] GO:0006897 [endocytosis] GO:0006898 [receptor-mediated endocytosis] GO:0007166 [cell surface receptor signaling pathway] GO:0008329 [signaling pattern recognition receptor activity] GO:0016020 [membrane] GO:0030666 [endocytic vesicle membrane] GO:0043277 [apoptotic cell clearance] GO:0045087 [innate immune response] Show all	520 aa 52.7 kDa	No	1
MARCO-003 ENSP00000409192 ENST00000412481	C9JKT8 [Direct mapping] Macrophage receptor MARCO Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		64 aa 7.2 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.