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Cell line enhanced (ASC TERT1, HL-60, Karpas-707, U-87 MG)
HPA (normal tissue):
Tissue enriched (placenta)
Protein evidence
Evidence at protein level
Protein expression normal tissue
Cytoplasmic expression and extracellular staining at variable levels in most tissues.
ANTIBODY IHC RELIABILITY
Data reliability description
Antibody staining not consistent with RNA expression data. Secreted protein, tissue location of RNA and protein might differ and correlation is complex. Pending external verification.
Most cancers displayed weak to moderate cytoplasmic staining with additional membranous positivity in some cases. Occasional cases of carcinoid, breast, colorectal, prostate and endometrial cancers showed strong immunoreactivity. Many cases of squamous and basal cell carcinomas along with lymphomas and melanomas were negative.
Cancer tissues displayed moderate to strong cytoplasmic staining. Several cases of skin, testicular and cervical cancers were weakly stained or negative.
This gene encodes a protein that binds to the hepatocyte growth factor receptor to regulate cell growth, cell motility and morphogenesis in numerous cell and tissue types. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate alpha and beta chains, which form the mature heterodimer. This protein is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. This protein also plays a role in angiogenesis, tumorogenesis, and tissue regeneration. Although the encoded protein is a member of the peptidase S1 family of serine proteases, it lacks peptidase activity. Mutations in this gene are associated with nonsyndromic hearing loss. [provided by RefSeq, Nov 2015]
Predicted intracellular proteins RAS pathway related proteins Cancer-related genes Mutational cancer driver genes Protein evidence (Ezkurdia et al 2014)