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A majority of malignant cells were negative. Some malignant gliomas, melanomas and testicular cancers showed moderate to strong nuclear and cytoplasmic staining.
The protein encoded by this gene, along with cyclin H and CDK7, forms the CDK-activating kinase (CAK) enzymatic complex. This complex activates several cyclin-associated kinases and can also associate with TFIIH to activate transcription by RNA polymerase II. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]