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RUNX3

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GENERAL INFORMATION

Gene name

 RUNX3

Gene description

 Runt-related transcription factor 3

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

Summary

 Mainly localized to the nucleus. In addition localized to the cytosol.

RNA cell category

 Cell line enhanced (Karpas-707, HDLM-2, SK-MEL-30)

Protein evidence

 Evidence at protein level

Main location

 Localized to the Nucleus (supported)

Additional location

 In addition localized to the Cytosol (supported)

Mouse

 Localized to the Nucleoplasm, Vesicles in mouse cells.

DATA RELIABILITY

Reliability score

 Supported based on 1 antibody.
HPA004195
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ASSAYS
RNA expression
Human cells
Mouse cells

RNA EXPRESSION OVERVIEW
RNA cell line category: Cell line enhanced (Karpas-707, HDLM-2, SK-MEL-30)
Organ
Origin
Category
Expression
Alphabetical
Cell lines sorted after organ of phenotypic resemblance.

HUMAN CELLS

Summary

 Mainly localized to the nucleus. In addition localized to the cytosol.

Main location

 Nucleus (supported)

Additional location

 Cytosol (supported)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location

Single-cell variation

Cell cycle dependent variation
HPA004195 A549 Nucleus
Vesicles
HPA004195 SiHa Nucleus
Nucleoli
Cytosol
HPA004195 U-2 OS Nucleus
Cytosol

MOUSE CELLS

Main location

 Nucleoplasm, Vesicles

Mouse gene

 ENSMUSG00000070691 (version 83)

 

 

 
Toggle channels
Low
High
G1
S
G2
M
N/A

Thumbnail

Antibody

Cell line

Location
HPA004195 NIH 3T3 Nucleoplasm
Vesicles

GENE INFORMATION

Gene name

 RUNX3 (HGNC Symbol)

Synonyms

 AML2, CBFA3, PEBP2A3

Description

 Runt-related transcription factor 3 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the runt domain-containing family of transcription factors. A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription. It also interacts with other transcription factors. It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p36.11

Chromosome location (bp)

 24899511 - 24965121

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000020633 (version 83.38)

Entrez gene

 864

UniProt

 Q13761 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13761

Antibodypedia

 RUNX3 antibodies

PROTEIN BROWSER
RUNX3-001
RUNX3-002
RUNX3-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
RUNX3-001
ENSP00000308051
ENST00000308873
Q13761 [Direct mapping]
Runt-related transcription factor 3
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001503 [ossification]
GO:0002062 [chondrocyte differentiation]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006468 [protein phosphorylation]
GO:0030097 [hemopoiesis]
GO:0030182 [neuron differentiation]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045595 [regulation of cell differentiation]
GO:0045786 [negative regulation of cell cycle]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048935 [peripheral nervous system neuron development]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0071559 [response to transforming growth factor beta]
Show all
 415 aa
44.4 kDa 		No 0
RUNX3-002
ENSP00000343477
ENST00000338888
Q13761 [Direct mapping]
Runt-related transcription factor 3
A0A024RAH4 [Target identity:100%; Query identity:100%]
Runt-related transcription factor 3, isoform CRA_b
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001503 [ossification]
GO:0002062 [chondrocyte differentiation]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006468 [protein phosphorylation]
GO:0030097 [hemopoiesis]
GO:0030182 [neuron differentiation]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045595 [regulation of cell differentiation]
GO:0045786 [negative regulation of cell cycle]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048935 [peripheral nervous system neuron development]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0071559 [response to transforming growth factor beta]
Show all
 429 aa
45.9 kDa 		No 0
RUNX3-201
ENSP00000382800
ENST00000399916
Q13761 [Direct mapping]
Runt-related transcription factor 3
A0A024RAH4 [Target identity:100%; Query identity:100%]
Runt-related transcription factor 3, isoform CRA_b
Show all
Predicted intracellular proteins
Transcription factors
   Immunoglobulin fold
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0000122 [negative regulation of transcription from RNA polymerase II promoter]
GO:0000790 [nuclear chromatin]
GO:0000977 [RNA polymerase II regulatory region sequence-specific DNA binding]
GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding]
GO:0001503 [ossification]
GO:0002062 [chondrocyte differentiation]
GO:0003677 [DNA binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005634 [nucleus]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0005794 [Golgi apparatus]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0006366 [transcription from RNA polymerase II promoter]
GO:0006468 [protein phosphorylation]
GO:0007411 [axon guidance]
GO:0030097 [hemopoiesis]
GO:0030182 [neuron differentiation]
GO:0031069 [hair follicle morphogenesis]
GO:0031175 [neuron projection development]
GO:0032609 [interferon-gamma production]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0045595 [regulation of cell differentiation]
GO:0045786 [negative regulation of cell cycle]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0048469 [cell maturation]
GO:0048935 [peripheral nervous system neuron development]
GO:0050680 [negative regulation of epithelial cell proliferation]
GO:0071559 [response to transforming growth factor beta]
GO:2001238 [positive regulation of extrinsic apoptotic signaling pathway]
Show all
 429 aa
45.9 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.