Expression of CYP3A43 in cancer - Summary - The Human Protein Atlas

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CYP3A43

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TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	CYP3A43
Gene description	Cytochrome P450, family 3, subfamily A, polypeptide 43
Protein class	Enzymes Plasma proteins Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Tissue enriched (liver cancer)
HPA (cell line):	Not detected
HPA (normal tissue):	Tissue enriched (liver)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Granular cytoplasmic expression mainly in liver and kidney

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. External characterization data supports antibody staining.
Reliability score	Supported based on 1 antibody. HPA066463
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (favourable).
Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Tissue enriched (liver cancer)

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA066463

GENE INFORMATION
Gene name	CYP3A43
Synonyms
Description	Cytochrome P450, family 3, subfamily A, polypeptide 43 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The encoded protein has a low level of testosterone hydroxylase activity, and may play a role in aging mechanisms and cancer progression. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Alternate splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2013]
Chromosome	7
Cytoband	q22.1
Chromosome location (bp)	99828013 - 99866102
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000021461 (version 83.38)
Entrez gene	64816
UniProt	Q9HB55 (UniProt - Evidence at protein level)
neXtProt	NX_Q9HB55
Antibodypedia	CYP3A43 antibodies

PROTEIN BROWSER

CYP3A43-001	CYP3A43-003	CYP3A43-005	CYP3A43-006	CYP3A43-013	CYP3A43-014	CYP3A43-201	CYP3A43-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
CYP3A43-001 ENSP00000346887 ENST00000354829	Q9HB55 [Direct mapping] Cytochrome P450 3A43 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Show all	GO:0004497 [monooxygenase activity] GO:0005506 [iron ion binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006805 [xenobiotic metabolic process] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0020037 [heme binding] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:0070330 [aromatase activity] Show all	503 aa 57.7 kDa	No	1
CYP3A43-003 ENSP00000416581 ENST00000417625	Q9HB55 [Direct mapping] Cytochrome P450 3A43 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Plasma proteins Show all	GO:0004497 [monooxygenase activity] GO:0005506 [iron ion binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006805 [xenobiotic metabolic process] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0020037 [heme binding] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:0070330 [aromatase activity] Show all	393 aa 44.8 kDa	No	2
CYP3A43-005 ENSP00000405557 ENST00000444905	C9JA26 [Direct mapping] Cytochrome P450 3A43 Show all	MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins Predicted intracellular proteins Show all	GO:0004497 [monooxygenase activity] GO:0005506 [iron ion binding] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0020037 [heme binding] GO:0055114 [oxidation-reduction process] Show all	167 aa 19.1 kDa	No	0
CYP3A43-006 ENSP00000401521 ENST00000415413	E9PDL8 [Direct mapping] Cytochrome P450 3A43 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0004497 [monooxygenase activity] GO:0005506 [iron ion binding] GO:0016021 [integral component of membrane] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0020037 [heme binding] GO:0055114 [oxidation-reduction process] Show all	292 aa 33.3 kDa	No	2
CYP3A43-013 ENSP00000312110 ENST00000312017	Q9HB55 [Direct mapping] Cytochrome P450 3A43 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Show all	GO:0004497 [monooxygenase activity] GO:0005506 [iron ion binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006805 [xenobiotic metabolic process] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0020037 [heme binding] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:0070330 [aromatase activity] Show all	420 aa 48.3 kDa	No	1
CYP3A43-014 ENSP00000222382 ENST00000222382	Q9HB55 [Direct mapping] Cytochrome P450 3A43 Show all	Enzymes ENZYME proteins Oxidoreductases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Show all	GO:0004497 [monooxygenase activity] GO:0005506 [iron ion binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006805 [xenobiotic metabolic process] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0020037 [heme binding] GO:0044281 [small molecule metabolic process] GO:0055114 [oxidation-reduction process] GO:0070330 [aromatase activity] Show all	504 aa 57.8 kDa	No	1
CYP3A43-201 ENSP00000345351 ENST00000342499	F8W6L8 [Direct mapping] Cytochrome P450 3A43 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Show all	GO:0005506 [iron ion binding] GO:0016021 [integral component of membrane] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0020037 [heme binding] GO:0055114 [oxidation-reduction process] Show all	126 aa 14.6 kDa	No	2
CYP3A43-202 ENSP00000486759 ENST00000631161	Q9HB50 [Direct mapping] Cytochrome P450 3A43; Cytochrome P450 subfamily IIIA polypeptide 43 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Show all	GO:0005506 [iron ion binding] GO:0016021 [integral component of membrane] GO:0016705 [oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen] GO:0020037 [heme binding] GO:0055114 [oxidation-reduction process] Show all	74 aa 8.6 kDa	No	1

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