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SLC7A9

GENERAL INFORMATION

Gene name

 SLC7A9

Gene description

 Solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9

Protein class

 Disease related genes
Potential drug targets
Predicted membrane proteins
Transporters

Predicted localization

 Membrane

Number of transcripts

 3
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HUMAN PROTEIN ATLAS INFORMATION

RNA tissue category
HPA:Group enriched (duodenum, kidney, small intestine)
GTEx:Tissue enriched (small intestine)
FANTOM5:Tissue enhanced (colon, small intestine)

Protein evidence

 Evidence at protein level

Protein expression

 Expression in brush border membrane of kidney and small intestine.

DATA RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA042591
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RNA AND PROTEIN EXPRESSION SUMMARY
RNA expression (TPM) Protein expression (score)
Brain
Caudate
N/A
Endocrine tissues
Bone marrow & immune system
Muscle tissues
Lung
Bronchus
N/A
Liver & gallbladder
Pancreas
Gastrointestinal tract
Kidney & urinary bladder
Male tissues
Female tissues
Vagina
N/A
Adipose & soft tissue
Skin
Cerebral cortex

Lymph node

Liver

Small intestine

Colon

Kidney

Testis

PROTEIN EXPRESSION OVERVIEW
Organ
Expression
Alphabetical

RNA EXPRESSION OVERVIEW
HPA dataset
Organ
Expression
Alphabetical
RNA tissue category: Group enriched (duodenum, kidney, small intestine)
GTEx dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enriched (small intestine)
FANTOM5 dataset
Organ
Expression
Alphabetical
RNA tissue category: Tissue enhanced (colon, small intestine)

GENE INFORMATION

Gene name

 SLC7A9 (HGNC Symbol)

Synonyms

 CSNU3

Description

 Solute carrier family 7 (amino acid transporter light chain, bo,+ system), member 9 (HGNC Symbol)

Entrez gene summary

 This gene encodes a protein that belongs to a family of light subunits of amino acid transporters. This protein plays a role in the high-affinity and sodium-independent transport of cystine and neutral and dibasic amino acids, and appears to function in the reabsorption of cystine in the kidney tubule. Mutations in this gene cause non-type I cystinuria, a disease that leads to cystine stones in the urinary system due to impaired transport of cystine and dibasic amino acids. Alternate transcript variants, which encode the same protein, have been found for this gene. [provided by RefSeq, Jul 2011]

Chromosome

 19

Cytoband

 q13.11

Chromosome location (bp)

 32830509 - 32869766

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000021488 (version 83.38)

Entrez gene

 11136

UniProt

 P82251 (UniProt - Evidence at protein level)

neXtProt

 NX_P82251

Antibodypedia

 SLC7A9 antibodies

PROTEIN BROWSER
SLC7A9-001
SLC7A9-002
SLC7A9-006

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SLC7A9-001
ENSP00000023064
ENST00000023064
P82251 [Direct mapping]
b(0,+)-type amino acid transporter 1
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Protein evidence (Kim et al 2014)
Show all
GO:0003333 [amino acid transmembrane transport]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006461 [protein complex assembly]
GO:0006811 [ion transport]
GO:0006865 [amino acid transport]
GO:0007596 [blood coagulation]
GO:0015171 [amino acid transmembrane transporter activity]
GO:0015175 [neutral amino acid transmembrane transporter activity]
GO:0015184 [L-cystine transmembrane transporter activity]
GO:0015297 [antiporter activity]
GO:0015804 [neutral amino acid transport]
GO:0015811 [L-cystine transport]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0031526 [brush border membrane]
GO:0042605 [peptide antigen binding]
GO:0050900 [leukocyte migration]
GO:0055085 [transmembrane transport]
Show all
 487 aa
53.5 kDa 		No >9
SLC7A9-002
ENSP00000468439
ENST00000587772
P82251 [Direct mapping]
b(0,+)-type amino acid transporter 1
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Show all
GO:0003333 [amino acid transmembrane transport]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006461 [protein complex assembly]
GO:0006811 [ion transport]
GO:0006865 [amino acid transport]
GO:0007596 [blood coagulation]
GO:0015171 [amino acid transmembrane transporter activity]
GO:0015175 [neutral amino acid transmembrane transporter activity]
GO:0015184 [L-cystine transmembrane transporter activity]
GO:0015297 [antiporter activity]
GO:0015804 [neutral amino acid transport]
GO:0015811 [L-cystine transport]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0031526 [brush border membrane]
GO:0042605 [peptide antigen binding]
GO:0050900 [leukocyte migration]
GO:0055085 [transmembrane transport]
Show all
 487 aa
53.5 kDa 		No >9
SLC7A9-006
ENSP00000464822
ENST00000590341
P82251 [Direct mapping]
b(0,+)-type amino acid transporter 1
Show all
Transporters
   Electrochemical Potential-driven transporters
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   >9TM proteins predicted by MDM
Disease related genes
Potential drug targets
Show all
GO:0003333 [amino acid transmembrane transport]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0006461 [protein complex assembly]
GO:0006811 [ion transport]
GO:0006865 [amino acid transport]
GO:0007596 [blood coagulation]
GO:0015171 [amino acid transmembrane transporter activity]
GO:0015175 [neutral amino acid transmembrane transporter activity]
GO:0015184 [L-cystine transmembrane transporter activity]
GO:0015297 [antiporter activity]
GO:0015804 [neutral amino acid transport]
GO:0015811 [L-cystine transport]
GO:0016020 [membrane]
GO:0016324 [apical plasma membrane]
GO:0031526 [brush border membrane]
GO:0042605 [peptide antigen binding]
GO:0050900 [leukocyte migration]
GO:0055085 [transmembrane transport]
Show all
 487 aa
53.5 kDa 		No >9

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.