Expression of OSBPL5 in cancer - Summary - The Human Protein Atlas

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OSBPL5

TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	OSBPL5
Gene description	Oxysterol binding protein-like 5
Protein class	Plasma proteins Predicted intracellular proteins Predicted membrane proteins Transporters
Predicted localization	Intracellular,Membrane
Number of transcripts	11
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (NB-4)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression with a granular pattern.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 2 antibodies. HPA038712 , HPA058727
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PROGNOSTIC SUMMARY
Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA038712	HPA058727

GENE INFORMATION
Gene name	OSBPL5 (HGNC Symbol)
Synonyms	KIAA1534, ORP5
Description	Oxysterol binding protein-like 5 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors that play a key role in the maintenance of cholesterol balance in the body. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. This gene has been shown to be imprinted, with preferential expression from the maternal allele only in placenta. Transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]
Chromosome	11
Cytoband	p15.4
Chromosome location (bp)	3087116 - 3166739
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000021762 (version 83.38)
Entrez gene	114879
UniProt	Q9H0X9 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H0X9
Antibodypedia	OSBPL5 antibodies

PROTEIN BROWSER

OSBPL5-001	OSBPL5-002	OSBPL5-004	OSBPL5-010	OSBPL5-011	OSBPL5-012	OSBPL5-014	OSBPL5-015	OSBPL5-016	OSBPL5-017	OSBPL5-018

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
OSBPL5-001 ENSP00000263650 ENST00000263650	Q9H0X9 [Direct mapping] Oxysterol-binding protein-related protein 5 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001786 [phosphatidylserine binding] GO:0005548 [phospholipid transporter activity] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0006893 [Golgi to plasma membrane transport] GO:0008142 [oxysterol binding] GO:0008203 [cholesterol metabolic process] GO:0015485 [cholesterol binding] GO:0015914 [phospholipid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030301 [cholesterol transport] GO:0070273 [phosphatidylinositol-4-phosphate binding] Show all	879 aa 98.6 kDa	No	1
OSBPL5-002 ENSP00000374639 ENST00000389989	Q9H0X9 [Direct mapping] Oxysterol-binding protein-related protein 5 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001786 [phosphatidylserine binding] GO:0005548 [phospholipid transporter activity] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0006893 [Golgi to plasma membrane transport] GO:0008142 [oxysterol binding] GO:0008203 [cholesterol metabolic process] GO:0015485 [cholesterol binding] GO:0015914 [phospholipid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030301 [cholesterol transport] GO:0070273 [phosphatidylinositol-4-phosphate binding] Show all	811 aa 90.8 kDa	No	1
OSBPL5-004 ENSP00000437141 ENST00000478260	E9PNH0 [Direct mapping] Oxysterol-binding protein-related protein 5 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all		333 aa 37.8 kDa	No	1
OSBPL5-010 ENSP00000435812 ENST00000530372	E9PIJ6 [Direct mapping] Oxysterol-binding protein-related protein 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		98 aa 10.8 kDa	No	0
OSBPL5-011 ENSP00000432507 ENST00000533721	E9PQB4 [Direct mapping] Oxysterol-binding protein-related protein 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		90 aa 9.9 kDa	No	0
OSBPL5-012 ENSP00000433222 ENST00000534157	E9PLN3 [Direct mapping] Oxysterol-binding protein-related protein 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		69 aa 7.6 kDa	No	0
OSBPL5-014 ENSP00000436950 ENST00000533234	E9PPQ2 [Direct mapping] Oxysterol-binding protein-related protein 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		139 aa 15.5 kDa	No	0
OSBPL5-015 ENSP00000302872 ENST00000348039	Q9H0X9 [Direct mapping] Oxysterol-binding protein-related protein 5 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001786 [phosphatidylserine binding] GO:0005548 [phospholipid transporter activity] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0006893 [Golgi to plasma membrane transport] GO:0008142 [oxysterol binding] GO:0008203 [cholesterol metabolic process] GO:0015485 [cholesterol binding] GO:0015914 [phospholipid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030301 [cholesterol transport] GO:0070273 [phosphatidylinositol-4-phosphate binding] Show all	811 aa 90.8 kDa	No	1
OSBPL5-016 ENSP00000433342 ENST00000525498	Q9H0X9 [Direct mapping] Oxysterol-binding protein-related protein 5 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Plasma proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0001786 [phosphatidylserine binding] GO:0005548 [phospholipid transporter activity] GO:0005789 [endoplasmic reticulum membrane] GO:0005829 [cytosol] GO:0006893 [Golgi to plasma membrane transport] GO:0008142 [oxysterol binding] GO:0008203 [cholesterol metabolic process] GO:0015485 [cholesterol binding] GO:0015914 [phospholipid transport] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0030301 [cholesterol transport] GO:0070273 [phosphatidylinositol-4-phosphate binding] Show all	790 aa 88.4 kDa	No	1
OSBPL5-017 ENSP00000431412 ENST00000534454	H0YCD7 [Direct mapping] Oxysterol-binding protein Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006869 [lipid transport] Show all	432 aa 48.9 kDa	No	1
OSBPL5-018 ENSP00000433754 ENST00000526122	E9PJE6 [Direct mapping] Oxysterol-binding protein-related protein 5 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		124 aa 13.9 kDa	No	0

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The Human Protein Atlas

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