Expression of SLC45A4 in cancer - Summary - The Human Protein Atlas

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SLC45A4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	SLC45A4
Gene description	Solute carrier family 45, member 4
Protein class	Predicted membrane proteins Transporters
Predicted localization	Membrane
Number of transcripts	5
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic and membranous expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Pending external verification. Caution, Splice and/or transcript discrepancy exists.
Reliability score	Uncertain based on 1 antibody. HPA023154
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA023154

GENE INFORMATION
Gene name	SLC45A4 (HGNC Symbol)
Synonyms	KIAA1126
Description	Solute carrier family 45, member 4 (HGNC Symbol)
Entrez gene summary
Chromosome	8
Cytoband	q24.3
Chromosome location (bp)	141207166 - 141308305
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000022567 (version 83.38)
Entrez gene	57210
UniProt	Q5BKX6 (UniProt - Evidence at protein level)
neXtProt	NX_Q5BKX6
Antibodypedia	SLC45A4 antibodies

PROTEIN BROWSER

SLC45A4-001	SLC45A4-002	SLC45A4-003	SLC45A4-004	SLC45A4-005

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
SLC45A4-001 ENSP00000024061 ENST00000024061	Q5BKX6 [Direct mapping] Solute carrier family 45 member 4 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006810 [transport] GO:0016021 [integral component of membrane] Show all	798 aa 87.6 kDa	No	>9
SLC45A4-002 ENSP00000429059 ENST00000519067	Q5BKX6 [Direct mapping] Solute carrier family 45 member 4 Show all	Transporters Electrochemical Potential-driven transporters Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0006810 [transport] GO:0016021 [integral component of membrane] Show all	717 aa 78.2 kDa	No	>9
SLC45A4-003 ENSP00000428137 ENST00000517878	E7EV90 [Direct mapping] Solute carrier family 45 member 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based >9TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	808 aa 88.7 kDa	No	>9
SLC45A4-004 ENSP00000429974 ENST00000519986	E5RGN5 [Direct mapping] Solute carrier family 45 member 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 3TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	102 aa 11 kDa	No	3
SLC45A4-005 ENSP00000429033 ENST00000520137	E5RJM7 [Direct mapping] Solute carrier family 45 member 4 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	96 aa 10.4 kDa	No	2

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.