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Most of the malignancies showed weak to moderate cytoplasmic and/or membranous positivity. A few endometrial and pancreatic cancers were strongly stained. Several malignant melanomas, squamous cell carcinomas and thyroid cancers were negative.
Non-Hodgkin's lymphomas showed moderate to strong cytoplasmic and membranous staining. Remaining malignant cells were in general negative. Inflammatory cells in stroma were distinctly stained.
DEF6, or IBP, is a guanine nucleotide exchange factor (GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is highly expressed in B and T cells (Gupta et al., 2003 [PubMed 12923183]).[supplied by OMIM, Mar 2008]