Expression of DEF6 in cancer - Summary - The Human Protein Atlas

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DEF6

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	DEF6
Gene description	DEF6 guanine nucleotide exchange factor
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (U-937)
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in immune cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 2 antibodies. HPA038975 , HPA038976
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable), breast cancer (favourable), cervical cancer (favourable), colorectal cancer (unfavourable) and endometrial cancer (favourable).
Renal cancer p<0.001 Breast cancer p<0.001 Cervical cancer p<0.001 Colorectal cancer p<0.001 Endometrial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA038975	HPA038976

GENE INFORMATION
Gene name	DEF6 (HGNC Symbol)
Synonyms	IBP, SLAT, SWAP70L
Description	DEF6 guanine nucleotide exchange factor (HGNC Symbol)
Entrez gene summary	DEF6, or IBP, is a guanine nucleotide exchange factor (GEF) for RAC (MIM 602048) and CDC42 (MIM 116952) that is highly expressed in B and T cells (Gupta et al., 2003 [PubMed 12923183]).[supplied by OMIM, Mar 2008]
Chromosome	6
Cytoband	p21.31
Chromosome location (bp)	35297852 - 35321771
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000023892 (version 83.38)
Entrez gene	50619
UniProt	Q9H4E7 (UniProt - Evidence at protein level)
neXtProt	NX_Q9H4E7
Antibodypedia	DEF6 antibodies

PROTEIN BROWSER

DEF6-001	DEF6-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
DEF6-001 ENSP00000319831 ENST00000316637	Q9H4E7 [Direct mapping] Differentially expressed in FDCP 6 homolog Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0016020 [membrane] Show all	631 aa 73.9 kDa	No	0
DEF6-002 ENSP00000415357 ENST00000444278	H0Y7V7 [Direct mapping] Differentially-expressed in FDCP 6 homolog Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		129 aa 14.7 kDa	No	0

Contact

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.