Expression of PLEKHO1 in cancer - Summary - The Human Protein Atlas

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PLEKHO1

TISSUE

CELL

PATHOLOGY

GENERAL INFORMATION
Gene name	PLEKHO1
Gene description	Pleckstrin homology domain containing, family O member 1
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	2
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Mixed

Protein evidence

Evidence at protein level

ANTIBODY IHC RELIABILITY
Reliability score	Pending cancer tissue analysis.

PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Pending cancer tissue analysis
STAINING SUMMARY

GENE INFORMATION
Gene name	PLEKHO1 (HGNC Symbol)
Synonyms	CKIP-1, OC120
Description	Pleckstrin homology domain containing, family O member 1 (HGNC Symbol)
Entrez gene summary
Chromosome	1
Cytoband	q21.2
Chromosome location (bp)	150149183 - 150164720
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000023902 (version 83.38)
Entrez gene	51177
UniProt	Q53GL0 (UniProt - Evidence at protein level)
neXtProt	NX_Q53GL0
Antibodypedia	PLEKHO1 antibodies

PROTEIN BROWSER

PLEKHO1-001	PLEKHO1-002

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PLEKHO1-001 ENSP00000358120 ENST00000369124	Q53GL0 [Direct mapping] Pleckstrin homology domain-containing family O member 1 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005737 [cytoplasm] GO:0005886 [plasma membrane] GO:0007520 [myoblast fusion] GO:0008360 [regulation of cell shape] GO:0032587 [ruffle membrane] GO:0036195 [muscle cell projection membrane] GO:0051451 [myoblast migration] GO:0072673 [lamellipodium morphogenesis] Show all	409 aa 46.2 kDa	No	0
PLEKHO1-002 ENSP00000358122 ENST00000369126	Q5T4P9 [Direct mapping] Pleckstrin homology domain containing, family O member 1; Pleckstrin homology domain containing, family O member 1, isoform CRA_c; Pleckstrin homology domain-containing family O member 1 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		226 aa 25.4 kDa	No	0

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.