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PHF20

GENERAL INFORMATION

Gene name

 PHF20

Gene description

 PHD finger protein 20

Protein class

 Cancer-related genes
Plasma proteins
Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear and nuclear membrane expression in most tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data. Pending external verification.

Reliability score

 Approved based on 2 antibodies.
HPA029619 , HPA029621
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA029619
HPA029621

GENE INFORMATION

Gene name

 PHF20 (HGNC Symbol)

Synonyms

 C20orf104, dJ1121G12.1, TDRD20A

Description

 PHD finger protein 20 (HGNC Symbol)

Entrez gene summary

Chromosome

 20

Cytoband

Chromosome location (bp)

 35771974 - 35950381

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000025293 (version 83.38)

Entrez gene

 51230

UniProt

 Q9BVI0 (UniProt - Evidence at protein level)

neXtProt

 NX_Q9BVI0

Antibodypedia

 PHF20 antibodies

PROTEIN BROWSER
PHF20-001
PHF20-003
PHF20-004
PHF20-012
PHF20-015
PHF20-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
PHF20-001
ENSP00000341900
ENST00000339089
Q5JWZ0 [Direct mapping]
PHD finger protein 20
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding]
GO:0005654 [nucleoplasm]
GO:0031965 [nuclear membrane]
GO:0046872 [metal ion binding]
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 543 aa
62.1 kDa 		No 0
PHF20-003
ENSP00000363124
ENST00000374012
Q9BVI0 [Direct mapping]
PHD finger protein 20
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Predicted intracellular proteins
Plasma proteins
Cancer-related genes
   Candidate cancer biomarkers
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0000123 [histone acetyltransferase complex]
GO:0003677 [DNA binding]
GO:0005515 [protein binding]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0006325 [chromatin organization]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0008270 [zinc ion binding]
GO:0031965 [nuclear membrane]
GO:0043981 [histone H4-K5 acetylation]
GO:0043982 [histone H4-K8 acetylation]
GO:0043984 [histone H4-K16 acetylation]
GO:0043995 [histone acetyltransferase activity (H4-K5 specific)]
GO:0043996 [histone acetyltransferase activity (H4-K8 specific)]
GO:0046872 [metal ion binding]
GO:0046972 [histone acetyltransferase activity (H4-K16 specific)]
GO:0071339 [MLL1 complex]
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 1012 aa
115.4 kDa 		No 0
PHF20-004
ENSP00000363112
ENST00000374000
Q5JXL1 [Direct mapping]
PHD finger protein 20
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0003677 [DNA binding]
GO:0005654 [nucleoplasm]
GO:0031965 [nuclear membrane]
GO:0046872 [metal ion binding]
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 549 aa
62.8 kDa 		No 0
PHF20-012
ENSP00000391915
ENST00000449988
B0QYY0 [Direct mapping]
PHD finger protein 20
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 154 aa
17.7 kDa 		No 0
PHF20-015
ENSP00000413712
ENST00000420233
B0QZ19 [Direct mapping]
PHD finger protein 20
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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 64 aa
7.5 kDa 		No 0
PHF20-201
ENSP00000410373
ENST00000439301
A0A0A0MT13 [Direct mapping]
PHD finger protein 20
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0046872 [metal ion binding]
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 638 aa
72.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.