Expression of NCAPH2 in cancer - Summary - The Human Protein Atlas

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NCAPH2

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TISSUE

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CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	NCAPH2
Gene description	Non-SMC condensin II complex, subunit H2
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Nuclear expression in proliferating cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Supported based on 1 antibody. HPA069056
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (favourable) and liver cancer (unfavourable).
Cervical cancer p<0.001 Liver cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA069056

GENE INFORMATION
Gene name	NCAPH2 (HGNC Symbol)
Synonyms	384D8-2, CAP-H2, hCAP-H2
Description	Non-SMC condensin II complex, subunit H2 (HGNC Symbol)
Entrez gene summary	This gene encodes one of the non-SMC subunits of the condensin II complex. This complex plays an essential role in mitotic chromosome assembly. Alternate splicing of this gene results in multiple transcript variants.[provided by RefSeq, May 2010]
Chromosome	22
Cytoband	q13.33
Chromosome location (bp)	50508216 - 50523472
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000025770 (version 83.38)
Entrez gene	29781
UniProt	Q6IBW4 (UniProt - Evidence at protein level)
neXtProt	NX_Q6IBW4
Antibodypedia	NCAPH2 antibodies

PROTEIN BROWSER

NCAPH2-001	NCAPH2-003	NCAPH2-006	NCAPH2-009	NCAPH2-012	NCAPH2-016

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NCAPH2-001 ENSP00000410088 ENST00000420993	Q6IBW4 [Direct mapping] Condensin-2 complex subunit H2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0016020 [membrane] GO:0030261 [chromosome condensation] Show all	605 aa 68.2 kDa	No	0
NCAPH2-003 ENSP00000379050 ENST00000395698	Q6IBW4 [Direct mapping] Condensin-2 complex subunit H2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0016020 [membrane] GO:0030261 [chromosome condensation] Show all	299 aa 32.8 kDa	No	0
NCAPH2-006 ENSP00000379053 ENST00000395701	A0A0A6YYG7 [Direct mapping] Condensin-2 complex subunit H2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		589 aa 66.3 kDa	No	0
NCAPH2-009 ENSP00000299821 ENST00000299821	Q6IBW4 [Direct mapping] Condensin-2 complex subunit H2 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0000278 [mitotic cell cycle] GO:0005515 [protein binding] GO:0005654 [nucleoplasm] GO:0005694 [chromosome] GO:0016020 [membrane] GO:0030261 [chromosome condensation] Show all	606 aa 68.3 kDa	No	0
NCAPH2-012 ENSP00000429025 ENST00000523045	E5RJN3 [Direct mapping] Condensin-2 complex subunit H2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		292 aa 32.2 kDa	No	0
NCAPH2-016 ENSP00000430944 ENST00000522304	H0YC55 [Direct mapping] Condensin-2 complex subunit H2 Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		141 aa 16 kDa	No	0

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.