Expression of TOMM34 in cancer - Summary

GENERAL INFORMATION
Gene name	TOMM34
Gene description	Translocase of outer mitochondrial membrane 34
Protein class	Predicted intracellular proteins
Predicted localization	Intracellular
Number of transcripts	1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues, highly abundant in spermatogonia in testis, ovarian follicles and subsets of immune cells.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Supported based on 2 antibodies. HPA018845 , HPA056875
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable), head and neck cancer (unfavourable) and thyroid cancer (favourable).
Liver cancer p<0.001 Head and neck cancer p<0.001 Thyroid cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

STAINING SUMMARY

HPA018845	HPA056875

GENE INFORMATION
Gene name	TOMM34 (HGNC Symbol)
Synonyms	HTOM34P, TOM34
Description	Translocase of outer mitochondrial membrane 34 (HGNC Symbol)
Entrez gene summary	The protein encoded by this gene is involved in the import of precursor proteins into mitochondria. The encoded protein has a chaperone-like activity, binding the mature portion of unfolded proteins and aiding their import into mitochondria. This protein, which is found in the cytoplasm and sometimes associated with the outer mitochondrial membrane, has a weak ATPase activity and contains 6 TPR repeats. [provided by RefSeq, Jul 2008]
Chromosome	20
Cytoband	q13.12
Chromosome location (bp)	44942130 - 44960486
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000025772 (version 83.38)
Entrez gene	10953
UniProt	Q15785 (UniProt - Evidence at protein level)
neXtProt	NX_Q15785
Antibodypedia	TOMM34 antibodies

PROTEIN BROWSER

TOMM34-001

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
TOMM34-001 ENSP00000361900 ENST00000372813	Q15785 [Direct mapping] Mitochondrial import receptor subunit TOM34 Show all	Predicted intracellular proteins Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0005737 [cytoplasm] GO:0005739 [mitochondrion] GO:0005741 [mitochondrial outer membrane] GO:0006626 [protein targeting to mitochondrion] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0031072 [heat shock protein binding] Show all	309 aa 34.6 kDa	No	0