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KPNA6

GENERAL INFORMATION

Gene name

 KPNA6

Gene description

 Karyopherin alpha 6 (importin alpha 7)

Protein class

 Plasma proteins
Predicted intracellular proteins
Transporters

Predicted localization

 Intracellular

Number of transcripts

 2
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous nuclear expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining consistent with RNA expression data.

Reliability score

 Supported based on 1 antibody.
HPA018863
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PROGNOSTIC SUMMARY
Prognostic marker in liver cancer (unfavourable).
Liver cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA018863

GENE INFORMATION

Gene name

 KPNA6 (HGNC Symbol)

Synonyms

 FLJ11249, IPOA7, KPNA7, MGC17918

Description

 Karyopherin alpha 6 (importin alpha 7) (HGNC Symbol)

Entrez gene summary

 Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. The protein encoded by this gene is a member of the importin alpha family. [provided by RefSeq, Jul 2008]

Chromosome

 1

Cytoband

 p35.2

Chromosome location (bp)

 32108038 - 32176568

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000025800 (version 83.38)

Entrez gene

 23633

UniProt

 O60684 (UniProt - Evidence at protein level)

neXtProt

 NX_O60684

Antibodypedia

 KPNA6 antibodies

PROTEIN BROWSER
KPNA6-001
KPNA6-004

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
KPNA6-001
ENSP00000362728
ENST00000373625
O60684 [Direct mapping]
Importin subunit alpha-7
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Transporters
   Transporter channels and pores
Predicted intracellular proteins
Plasma proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
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GO:0005488 [binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005643 [nuclear pore]
GO:0005654 [nucleoplasm]
GO:0005737 [cytoplasm]
GO:0005829 [cytosol]
GO:0006606 [protein import into nucleus]
GO:0006607 [NLS-bearing protein import into nucleus]
GO:0008139 [nuclear localization sequence binding]
GO:0008565 [protein transporter activity]
GO:0016020 [membrane]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0060135 [maternal process involved in female pregnancy]
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 536 aa
60 kDa 		No 0
KPNA6-004
ENSP00000415677
ENST00000446515
Q5TFJ7 [Direct mapping]
Importin subunit alpha-7
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
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GO:0005488 [binding]
GO:0005515 [protein binding]
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 321 aa
35.5 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.