Expression of RNASET2 in cancer - Summary - The Human Protein Atlas

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RNASET2

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	RNASET2
Gene description	Ribonuclease T2
Protein class	Disease related genes Predicted intracellular proteins Predicted secreted proteins
Predicted localization	Intracellular,Secreted
Number of transcripts	6
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (THP-1)
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General cytoplasmic expression, most abundant in lymphocytes.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 2 antibodies. HPA029013 , HPA066509
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

Endometrial cancer

STAINING SUMMARY

HPA029013	HPA066509

GENE INFORMATION
Gene name	RNASET2 (HGNC Symbol)
Synonyms	bA514O12.3, FLJ10907, RNASE6PL
Description	Ribonuclease T2 (HGNC Symbol)
Entrez gene summary	This ribonuclease gene is a novel member of the Rh/T2/S-glycoprotein class of extracellular ribonucleases. It is a single copy gene that maps to 6q27, a region associated with human malignancies and chromosomal rearrangement. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	q27
Chromosome location (bp)	166929504 - 166957191
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000026297 (version 83.38)
Entrez gene	8635
UniProt	O00584 (UniProt - Evidence at protein level)
neXtProt	NX_O00584
Antibodypedia	RNASET2 antibodies

PROTEIN BROWSER

RNASET2-001	RNASET2-004	RNASET2-006	RNASET2-007	RNASET2-201	RNASET2-202

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
RNASET2-001 ENSP00000426455 ENST00000508775	O00584 [Direct mapping] Ribonuclease T2 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0004521 [endoribonuclease activity] GO:0004540 [ribonuclease activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005764 [lysosome] GO:0005788 [endoplasmic reticulum lumen] GO:0006401 [RNA catabolic process] GO:0033897 [ribonuclease T2 activity] GO:0043202 [lysosomal lumen] GO:0070062 [extracellular exosome] GO:0090501 [RNA phosphodiester bond hydrolysis] GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic] Show all	256 aa 29.5 kDa	Yes	0
RNASET2-004 ENSP00000426059 ENST00000478180	D6RHI9 [Direct mapping] Ribonuclease T2 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0004521 [endoribonuclease activity] GO:0033897 [ribonuclease T2 activity] GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic] Show all	254 aa 29.2 kDa	Yes	0
RNASET2-006 ENSP00000422846 ENST00000476238	O00584 [Direct mapping] Ribonuclease T2 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Disease related genes Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0004521 [endoribonuclease activity] GO:0004540 [ribonuclease activity] GO:0005576 [extracellular region] GO:0005615 [extracellular space] GO:0005764 [lysosome] GO:0005788 [endoplasmic reticulum lumen] GO:0006401 [RNA catabolic process] GO:0033897 [ribonuclease T2 activity] GO:0043202 [lysosomal lumen] GO:0070062 [extracellular exosome] GO:0090501 [RNA phosphodiester bond hydrolysis] GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic] Show all	256 aa 29.5 kDa	Yes	0
RNASET2-007 ENSP00000424947 ENST00000366855	D6REQ6 [Direct mapping] Ribonuclease T2; Ribonuclease T2, isoform CRA_c Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0004521 [endoribonuclease activity] GO:0033897 [ribonuclease T2 activity] GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic] Show all	218 aa 25.3 kDa	No	0
RNASET2-201 ENSP00000480244 ENST00000611959	A0A087WWI1 [Direct mapping] Ribonuclease T2 Show all	Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0004521 [endoribonuclease activity] GO:0033897 [ribonuclease T2 activity] GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic] Show all	238 aa 26.3 kDa	Yes	0
RNASET2-202 ENSP00000482755 ENST00000620173	A0A087WZM2 [Direct mapping] Ribonuclease T2 Show all	MEMSAT3 predicted membrane proteins SCAMPI predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0003723 [RNA binding] GO:0004521 [endoribonuclease activity] GO:0033897 [ribonuclease T2 activity] GO:0090502 [RNA phosphodiester bond hydrolysis, endonucleolytic] Show all	306 aa 34.9 kDa	Yes	0

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The Human Protein Atlas

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