Expression of AGPAT4 in cancer - Summary - The Human Protein Atlas

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AGPAT4

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	AGPAT4
Gene description	1-acylglycerol-3-phosphate O-acyltransferase 4
Protein class	Enzymes Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Cell line enhanced (AF22)
HPA (normal tissue):	Tissue enhanced (cerebral cortex)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in most tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Pending external verification.
Reliability score	Approved based on 1 antibody. HPA053287
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PROGNOSTIC SUMMARY
Prognostic marker in cervical cancer (unfavourable) and renal cancer (unfavourable).
Cervical cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA053287

GENE INFORMATION
Gene name	AGPAT4 (HGNC Symbol)
Synonyms	dJ473J16.2, LPAAT-delta
Description	1-acylglycerol-3-phosphate O-acyltransferase 4 (HGNC Symbol)
Entrez gene summary	This gene encodes a member of the 1-acylglycerol-3-phosphate O-acyltransferase family. This integral membrane protein converts lysophosphatidic acid to phosphatidic acid, the second step in de novo phospholipid biosynthesis. [provided by RefSeq, Jul 2008]
Chromosome	6
Cytoband	q26
Chromosome location (bp)	161129979 - 161274061
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000026652 (version 83.38)
Entrez gene	56895
UniProt	Q9NRZ5 (UniProt - Evidence at protein level)
neXtProt	NX_Q9NRZ5
Antibodypedia	AGPAT4 antibodies

PROTEIN BROWSER

AGPAT4-001	AGPAT4-003	AGPAT4-004	AGPAT4-201

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
AGPAT4-001 ENSP00000314036 ENST00000320285	Q9NRZ5 [Direct mapping] 1-acyl-sn-glycerol-3-phosphate acyltransferase delta Show all	Enzymes ENZYME proteins Transferases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 4TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0003841 [1-acylglycerol-3-phosphate O-acyltransferase activity] GO:0005515 [protein binding] GO:0005789 [endoplasmic reticulum membrane] GO:0006644 [phospholipid metabolic process] GO:0006654 [phosphatidic acid biosynthetic process] GO:0008152 [metabolic process] GO:0008654 [phospholipid biosynthetic process] GO:0016021 [integral component of membrane] GO:0016024 [CDP-diacylglycerol biosynthetic process] GO:0016746 [transferase activity, transferring acyl groups] GO:0019432 [triglyceride biosynthetic process] GO:0044255 [cellular lipid metabolic process] GO:0044281 [small molecule metabolic process] GO:0046474 [glycerophospholipid biosynthetic process] Show all	378 aa 44 kDa	No	4
AGPAT4-003 ENSP00000355872 ENST00000366905	Q5TEE8 [Direct mapping] 1-acyl-sn-glycerol-3-phosphate acyltransferase delta; 1-acylglycerol-3-phosphate O-acyltransferase 4 (Lysophosphatidic acid acyltransferase, delta), isoform CRA_e Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 2TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0008152 [metabolic process] GO:0016021 [integral component of membrane] GO:0016746 [transferase activity, transferring acyl groups] Show all	159 aa 18.3 kDa	No	2
AGPAT4-004 ENSP00000400211 ENST00000437165	H0Y5R3 [Direct mapping] 1-acyl-sn-glycerol-3-phosphate acyltransferase delta Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all		105 aa 11.9 kDa	No	0
AGPAT4-201 ENSP00000355878 ENST00000366911	Q6AI25 [Direct mapping] 1-acyl-sn-glycerol-3-phosphate acyltransferase delta; Putative uncharacterized protein DKFZp686G10113 Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0016021 [integral component of membrane] Show all	118 aa 13.2 kDa	No	1

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The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.