Expression of BTN3A1 in cancer - Summary - The Human Protein Atlas

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BTN3A1

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	BTN3A1
Gene description	Butyrophilin, subfamily 3, member A1
Protein class	CD markers Predicted membrane proteins Predicted secreted proteins
Predicted localization	Membrane,Secreted
Number of transcripts	7
	SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Mixed
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Cytoplasmic expression in several tissues.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data.
Reliability score	Approved based on 1 antibody. HPA012565
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable) and urothelial cancer (favourable).
Renal cancer p<0.001 Urothelial cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA012565

GENE INFORMATION
Gene name	BTN3A1 (HGNC Symbol)
Synonyms	BT3.1, BTF5, BTN3.1, CD277
Description	Butyrophilin, subfamily 3, member A1 (HGNC Symbol)
Entrez gene summary	The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC)-associated genes that encode type I membrane proteins with 2 extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) domain. Three subfamilies of human BTN genes are located in the MHC class I region: the single-copy BTN1A1 gene (MIM 601610) and the BTN2 (e.g., BTN2A1; MIM 613590) and BTN3 (e.g., BNT3A1) genes, which have undergone tandem duplication, resulting in 3 copies of each (summary by Smith et al., 2010 [PubMed 20208008]).[supplied by OMIM, Nov 2010]
Chromosome	6
Cytoband	p22.2
Chromosome location (bp)	26402237 - 26415216
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000026950 (version 83.38)
Entrez gene	11119
UniProt	O00481 (UniProt - Evidence at protein level)
neXtProt	NX_O00481
Antibodypedia	BTN3A1 antibodies

PROTEIN BROWSER

BTN3A1-001	BTN3A1-002	BTN3A1-005	BTN3A1-006	BTN3A1-007	BTN3A1-009	BTN3A1-010

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
BTN3A1-001 ENSP00000289361 ENST00000289361	O00481 [Direct mapping] Butyrophilin subfamily 3 member A1 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002250 [adaptive immune response] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0050663 [cytokine secretion] GO:0050798 [activated T cell proliferation] GO:0050852 [T cell receptor signaling pathway] GO:0072643 [interferon-gamma secretion] Show all	513 aa 57.7 kDa	Yes	1
BTN3A1-002 ENSP00000420010 ENST00000476549	O00481 [Direct mapping] Butyrophilin subfamily 3 member A1 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0002250 [adaptive immune response] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0050663 [cytokine secretion] GO:0050798 [activated T cell proliferation] GO:0050852 [T cell receptor signaling pathway] GO:0072643 [interferon-gamma secretion] Show all	352 aa 39.4 kDa	Yes	1
BTN3A1-005 ENSP00000399393 ENST00000427334	A6PVC0 [Direct mapping] Butyrophilin subfamily 3 member A1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		43 aa 4.7 kDa	Yes	0
BTN3A1-006 ENSP00000406667 ENST00000414912	O00481 [Direct mapping] Butyrophilin subfamily 3 member A1 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0002250 [adaptive immune response] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0050663 [cytokine secretion] GO:0050798 [activated T cell proliferation] GO:0050852 [T cell receptor signaling pathway] GO:0072643 [interferon-gamma secretion] Show all	461 aa 52 kDa	Yes	1
BTN3A1-007 ENSP00000396684 ENST00000425234	O00481 [Direct mapping] Butyrophilin subfamily 3 member A1 Show all	CD markers Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0002250 [adaptive immune response] GO:0005515 [protein binding] GO:0005886 [plasma membrane] GO:0016021 [integral component of membrane] GO:0050663 [cytokine secretion] GO:0050798 [activated T cell proliferation] GO:0050852 [T cell receptor signaling pathway] GO:0072643 [interferon-gamma secretion] Show all	378 aa 41.8 kDa	Yes	1
BTN3A1-009 ENSP00000394937 ENST00000450085	E7EPR2 [Direct mapping] Butyrophilin subfamily 3 member A1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0005515 [protein binding] Show all	119 aa 13 kDa	Yes	0
BTN3A1-010 ENSP00000427013 ENST00000506698	E9PFB8 [Direct mapping] Butyrophilin subfamily 3 member A1 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins THUMBUP predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Protein evidence (Ezkurdia et al 2014) Show all		92 aa 10.2 kDa	Yes	0

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