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Field

Term
Gene name

Class

Subclass

Chromosome

External id

In atlas

Reliability

Reliability

Reliability

Validation

Method

Validation

Method

Validation

Method

Validation

Location

Searches

Tissue

Cell type

Expression

Tissue

Specificity

Cell line

Specificity

Cancer

Specificity

Tissue

Detectable

Cell line

Detectable

Cancer

Detectable

Cancer

Prognosis

Category

Score

Score

Score

Antibodies

Column

 
 
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INSRR
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PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary

Level of antibody staining/expression





High
Medium
Low
Not detected

GENERAL INFORMATION

Gene name

INSRR

Gene description

Insulin receptor-related receptor

Protein class

Enzymes
Predicted membrane proteins

Predicted localization

Membrane

Number of transcripts

1
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):Not detected
HPA (cell line):Group enriched (SCLC-21H, SH-SY5Y)
HPA (normal tissue):Tissue enhanced (adrenal gland, kidney, testis)

Protein evidence

Evidence at protein level

Protein expression
normal tissue

Estimation of protein expression could not be performed. View primary data.

ANTIBODY IHC RELIABILITY

Data reliability
description

RNA-based expert annotation gave inconclusive results. Pending external verification.

Reliability score

Uncertain based on 1 antibody.
HPA025285
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PROGNOSTIC SUMMARY

Gene product is not prognostic.
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RNA EXPRESSION OVERVIEW

TCGA dataset
RNA cancer category: Not detected

PROTEIN EXPRESSION

Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY

HPA025285

Cancer

Cancer staining

Breast cancer
Carcinoid
Cervical cancer
Colorectal cancer
Endometrial cancer
Glioma
Head and neck cancer
Liver cancer
Lung cancer
Lymphoma
 

Cancer

Cancer staining

Melanoma
Ovarian cancer
Pancreatic cancer
Prostate cancer
Renal cancer
Skin cancer
Stomach cancer
Testis cancer
Thyroid cancer
Urothelial cancer

Staining summary

Moderate to strong cytoplasmic and nuclear positivity was seen in most malignant cells. Malignant glioma showed mostly weak staining.

GENE INFORMATION

Gene name

INSRR (HGNC Symbol)

Synonyms

IRR

Description

Insulin receptor-related receptor (HGNC Symbol)

Entrez gene summary

Chromosome

1

Cytoband

q23.1

Chromosome location (bp)

156840063 - 156859018

Protein evidence

Evidence at protein level (all genes)

Ensembl

ENSG00000027644 (version 83.38)

Entrez gene

3645

UniProt

P14616 (UniProt - Evidence at protein level)

neXtProt

NX_P14616

Antibodypedia

INSRR antibodies

PROTEIN BROWSER

INSRR-001

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)

INSRR-001
ENSP00000357178
ENST00000368195
P14616 [Direct mapping]
Insulin receptor-related protein Insulin receptor-related protein alpha chain Insulin receptor-related protein beta chain
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Enzymes
   ENZYME proteins
   Transferases
   Kinases
   Tyr protein kinases
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Show all
GO:0004672 [protein kinase activity]
GO:0004713 [protein tyrosine kinase activity]
GO:0004714 [transmembrane receptor protein tyrosine kinase activity]
GO:0005515 [protein binding]
GO:0005524 [ATP binding]
GO:0005887 [integral component of plasma membrane]
GO:0006468 [protein phosphorylation]
GO:0007169 [transmembrane receptor protein tyrosine kinase signaling pathway]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0018108 [peptidyl-tyrosine phosphorylation]
GO:0030238 [male sex determination]
GO:0031532 [actin cytoskeleton reorganization]
GO:0043235 [receptor complex]
GO:0043548 [phosphatidylinositol 3-kinase binding]
GO:0043560 [insulin receptor substrate binding]
GO:0046777 [protein autophosphorylation]
GO:0071469 [cellular response to alkaline pH]
Show all
1297 aa
143.7 kDa
Yes 1

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