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IFNGR1

GENERAL INFORMATION

Gene name

 IFNGR1

Gene description

 Interferon gamma receptor 1

Protein class

 CD markers
Disease related genes
FDA approved drug targets
Predicted intracellular proteins
Predicted membrane proteins
Predicted secreted proteins

Predicted localization

 Intracellular,Membrane,Secreted

Number of transcripts

 4
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Membranous expression in subsets of immune cells in several tissues.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Presumed off target binding observed and disregarded. Antibody staining in cells/structures not annotated, view images.

Reliability score

 Approved based on 1 antibody.
HPA063871
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (unfavourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer

STAINING SUMMARY
HPA063871

GENE INFORMATION

Gene name

 IFNGR1 (HGNC Symbol)

Synonyms

 CD119, IFNGR

Description

 Interferon gamma receptor 1 (HGNC Symbol)

Entrez gene summary

 This gene (IFNGR1) encodes the ligand-binding chain (alpha) of the gamma interferon receptor. Human interferon-gamma receptor is a heterodimer of IFNGR1 and IFNGR2. A genetic variation in IFNGR1 is associated with susceptibility to Helicobacter pylori infection. In addition, defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease, also known as familial disseminated atypical mycobacterial infection. [provided by RefSeq, Jul 2008]

Chromosome

 6

Cytoband

 q23.3

Chromosome location (bp)

 137197484 - 137219449

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000027697 (version 83.38)

Entrez gene

 3459

UniProt

 P15260 (UniProt - Evidence at protein level)

neXtProt

 NX_P15260

Antibodypedia

 IFNGR1 antibodies

PROTEIN BROWSER
IFNGR1-001
IFNGR1-002
IFNGR1-003
IFNGR1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
IFNGR1-001
ENSP00000356713
ENST00000367739
P15260 [Direct mapping]
Interferon gamma receptor 1
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CD markers
Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Disease related genes
FDA approved drug targets
   Biotech drugs
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0004906 [interferon-gamma receptor activity]
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0005887 [integral component of plasma membrane]
GO:0007165 [signal transduction]
GO:0009615 [response to virus]
GO:0016020 [membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019955 [cytokine binding]
GO:0060333 [interferon-gamma-mediated signaling pathway]
GO:0060334 [regulation of interferon-gamma-mediated signaling pathway]
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 489 aa
54.4 kDa 		Yes 1
IFNGR1-002
ENSP00000389249
ENST00000458076
Q5TFC9 [Direct mapping]
Interferon gamma receptor 1
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Predicted secreted proteins
   Secreted proteins predicted by MDSEC
   SignalP predicted secreted proteins
   Phobius predicted secreted proteins
   SPOCTOPUS predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0016020 [membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019955 [cytokine binding]
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 210 aa
23.7 kDa 		Yes 0
IFNGR1-003
ENSP00000394230
ENST00000414770
Q5TFD1 [Direct mapping]
Interferon gamma receptor 1
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Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019955 [cytokine binding]
Show all
 161 aa
18.6 kDa 		No 0
IFNGR1-201
ENSP00000443282
ENST00000543628
F5H5M7 [Direct mapping]
Interferon gamma receptor 1
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Predicted membrane proteins
   Prediction method-based
   Membrane proteins predicted by MDM
   MEMSAT3 predicted membrane proteins
   MEMSAT-SVM predicted membrane proteins
   Phobius predicted membrane proteins
   SCAMPI predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
   THUMBUP predicted membrane proteins
   TMHMM predicted membrane proteins
   # TM segments-based
   1TM proteins predicted by MDM
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005515 [protein binding]
GO:0005886 [plasma membrane]
GO:0016020 [membrane]
GO:0016021 [integral component of membrane]
GO:0019221 [cytokine-mediated signaling pathway]
GO:0019955 [cytokine binding]
Show all
 274 aa
31 kDa 		Yes 1

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.