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SNX1

GENERAL INFORMATION

Gene name

 SNX1

Gene description

 Sorting nexin 1

Protein class

 Predicted intracellular proteins

Predicted localization

 Intracellular

Number of transcripts

 8
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HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Expressed in all
HPA (cell line):Expressed in all
HPA (normal tissue):Expressed in all

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Ubiquitous cytoplasmic expression.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Antibody staining mainly consistent with RNA expression data.

Reliability score

 Approved based on 1 antibody.
HPA047373
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PROGNOSTIC SUMMARY
Prognostic marker in renal cancer (favourable).
Renal cancer p<0.001
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RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Expressed in all

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA047373

GENE INFORMATION

Gene name

 SNX1 (HGNC Symbol)

Synonyms

 HsT17379, MGC8664, SNX1A, Vps5

Description

 Sorting nexin 1 (HGNC Symbol)

Entrez gene summary

 This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This endosomal protein regulates the cell-surface expression of epidermal growth factor receptor. This protein also has a role in sorting protease-activated receptor-1 from early endosomes to lysosomes. This protein may form oligomeric complexes with family members. This gene results in three transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]

Chromosome

 15

Cytoband

 q22.31

Chromosome location (bp)

 64094123 - 64146090

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000028528 (version 83.38)

Entrez gene

 6642

UniProt

 Q13596 (UniProt - Evidence at protein level)

neXtProt

 NX_Q13596

Antibodypedia

 SNX1 antibodies

PROTEIN BROWSER
SNX1-001
SNX1-002
SNX1-003
SNX1-004
SNX1-008
SNX1-009
SNX1-010
SNX1-201

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
SNX1-001
ENSP00000453785
ENST00000559844
Q13596 [Direct mapping]
Sorting nexin-1
Show all
   Phobius predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005154 [epidermal growth factor receptor binding]
GO:0005158 [insulin receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005794 [Golgi apparatus]
GO:0006886 [intracellular protein transport]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0016050 [vesicle organization]
GO:0019898 [extrinsic component of membrane]
GO:0030027 [lamellipodium]
GO:0030904 [retromer complex]
GO:0030905 [retromer, tubulation complex]
GO:0031623 [receptor internalization]
GO:0031901 [early endosome membrane]
GO:0034498 [early endosome to Golgi transport]
GO:0035091 [phosphatidylinositol binding]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043234 [protein complex]
GO:0046982 [protein heterodimerization activity]
GO:0072673 [lamellipodium morphogenesis]
GO:1990459 [transferrin receptor binding]
GO:1990460 [leptin receptor binding]
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 522 aa
59.1 kDa 		No 0
SNX1-002
ENSP00000453567
ENST00000561026
Q13596 [Direct mapping]
Sorting nexin-1
Show all
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005154 [epidermal growth factor receptor binding]
GO:0005158 [insulin receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005794 [Golgi apparatus]
GO:0006886 [intracellular protein transport]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0016050 [vesicle organization]
GO:0019898 [extrinsic component of membrane]
GO:0030027 [lamellipodium]
GO:0030904 [retromer complex]
GO:0030905 [retromer, tubulation complex]
GO:0031623 [receptor internalization]
GO:0031901 [early endosome membrane]
GO:0034498 [early endosome to Golgi transport]
GO:0035091 [phosphatidylinositol binding]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043234 [protein complex]
GO:0046982 [protein heterodimerization activity]
GO:0072673 [lamellipodium morphogenesis]
GO:1990459 [transferrin receptor binding]
GO:1990460 [leptin receptor binding]
Show all
 457 aa
51.8 kDa 		No 0
SNX1-003
ENSP00000261889
ENST00000261889
Q13596 [Direct mapping]
Sorting nexin-1
Show all
   Phobius predicted membrane proteins
   SPOCTOPUS predicted membrane proteins
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005154 [epidermal growth factor receptor binding]
GO:0005158 [insulin receptor binding]
GO:0005515 [protein binding]
GO:0005737 [cytoplasm]
GO:0005768 [endosome]
GO:0005769 [early endosome]
GO:0005794 [Golgi apparatus]
GO:0005829 [cytosol]
GO:0006886 [intracellular protein transport]
GO:0010008 [endosome membrane]
GO:0016020 [membrane]
GO:0016050 [vesicle organization]
GO:0016197 [endosomal transport]
GO:0019898 [extrinsic component of membrane]
GO:0030027 [lamellipodium]
GO:0030512 [negative regulation of transforming growth factor beta receptor signaling pathway]
GO:0030904 [retromer complex]
GO:0030905 [retromer, tubulation complex]
GO:0031623 [receptor internalization]
GO:0031901 [early endosome membrane]
GO:0034498 [early endosome to Golgi transport]
GO:0035091 [phosphatidylinositol binding]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0042802 [identical protein binding]
GO:0042803 [protein homodimerization activity]
GO:0043231 [intracellular membrane-bounded organelle]
GO:0043234 [protein complex]
GO:0045732 [positive regulation of protein catabolic process]
GO:0046982 [protein heterodimerization activity]
GO:0072673 [lamellipodium morphogenesis]
GO:1990459 [transferrin receptor binding]
GO:1990460 [leptin receptor binding]
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 557 aa
63.1 kDa 		No 0
SNX1-004
ENSP00000452651
ENST00000560829
H0YK42 [Direct mapping]
Sorting nexin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005768 [endosome]
GO:0006886 [intracellular protein transport]
GO:0016050 [vesicle organization]
GO:0019898 [extrinsic component of membrane]
GO:0030904 [retromer complex]
GO:0035091 [phosphatidylinositol binding]
GO:0042147 [retrograde transport, endosome to Golgi]
Show all
 304 aa
35.6 kDa 		No 0
SNX1-008
ENSP00000452652
ENST00000559061
H0YK43 [Direct mapping]
Sorting nexin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005768 [endosome]
GO:0016050 [vesicle organization]
GO:0019898 [extrinsic component of membrane]
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 19 aa
2.2 kDa 		No 0
SNX1-009
ENSP00000452668
ENST00000558040
H0YK58 [Direct mapping]
Sorting nexin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005768 [endosome]
GO:0006886 [intracellular protein transport]
GO:0016050 [vesicle organization]
GO:0019898 [extrinsic component of membrane]
GO:0030904 [retromer complex]
GO:0035091 [phosphatidylinositol binding]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 128 aa
13.6 kDa 		No 0
SNX1-010
ENSP00000452931
ENST00000560861
H0YKT3 [Direct mapping]
Sorting nexin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005768 [endosome]
GO:0006886 [intracellular protein transport]
GO:0016050 [vesicle organization]
GO:0019898 [extrinsic component of membrane]
GO:0030904 [retromer complex]
GO:0035091 [phosphatidylinositol binding]
GO:0042147 [retrograde transport, endosome to Golgi]
Show all
 70 aa
8.4 kDa 		No 0
SNX1-201
ENSP00000486714
ENST00000625244
H0YKD5 [Direct mapping]
Sorting nexin-1
Show all
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Show all
GO:0005768 [endosome]
GO:0006886 [intracellular protein transport]
GO:0016050 [vesicle organization]
GO:0019898 [extrinsic component of membrane]
GO:0030904 [retromer complex]
GO:0035091 [phosphatidylinositol binding]
GO:0042147 [retrograde transport, endosome to Golgi]
GO:0043231 [intracellular membrane-bounded organelle]
Show all
 107 aa
11.1 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.