Fields »
ABOUT
HELP
BLOG
ARNTL2

GENERAL INFORMATION

Gene name

 ARNTL2

Gene description

 Aryl hydrocarbon receptor nuclear translocator-like 2

Protein class

 Predicted intracellular proteins
Transcription factors

Predicted localization

 Intracellular

Number of transcripts

 8
SHOW MORE

HUMAN PROTEIN ATLAS INFORMATION

RNA category
TCGA (cancer tissue):Mixed
HPA (cell line):Cell line enhanced (U-2197)
HPA (normal tissue):Tissue enhanced (esophagus)

Protein evidence

 Evidence at protein level

Protein expression
normal tissue

 Nuclear membranous expression mainly in CNS.

ANTIBODY IHC RELIABILITY

Data reliability
description

 Presumed off target binding observed and disregarded.

Reliability score

 Uncertain based on 1 antibody.
HPA059074
SHOW MORE

PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (unfavourable) and renal cancer (unfavourable).
Pancreatic cancer p<0.001
Renal cancer p<0.001
Show all

RNA EXPRESSION OVERVIEW
TCGA dataset
RNA cancer category: Mixed

PROTEIN EXPRESSION
Colorectal cancer
Breast cancer
Prostate cancer
Lung cancer
Liver cancer

STAINING SUMMARY
HPA059074

GENE INFORMATION

Gene name

 ARNTL2 (HGNC Symbol)

Synonyms

 bHLHe6, BMAL2, CLIF, MOP9, PASD9

Description

 Aryl hydrocarbon receptor nuclear translocator-like 2 (HGNC Symbol)

Entrez gene summary

 This gene encodes a basic helix-loop-helix transcription factor belonging to the PAS (PER, ARNT, SIM) superfamily. The PAS proteins play important roles in adaptation to low atmospheric and cellular oxygen levels, exposure to certain environmental pollutants, and diurnal oscillations in light and temperature. This protein forms a transcriptionally active heterodimer with the circadian CLOCK protein, the structurally related MOP4, and hypoxia-inducible factors, such as HIF1alpha. Consistent with its role as a biologically relevant partner of circadian and hypoxia factors, this protein is coexpressed in regions of the brain such as the thalamus, hypothalamus, and amygdala. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Oct 2011]

Chromosome

 12

Cytoband

 p11.23

Chromosome location (bp)

 27332854 - 27425289

Protein evidence

 Evidence at protein level (all genes)

Ensembl

 ENSG00000029153 (version 83.38)

Entrez gene

 56938

UniProt

 Q8WYA1 (UniProt - Evidence at protein level)

neXtProt

 NX_Q8WYA1

Antibodypedia

 ARNTL2 antibodies

PROTEIN BROWSER
ARNTL2-001
ARNTL2-002
ARNTL2-003
ARNTL2-004
ARNTL2-005
ARNTL2-006
ARNTL2-007
ARNTL2-008

PROTEIN INFORMATION

Splice variant

UniProt

Protein class

Gene ontology

Length & mass

Signal peptide
(predicted)

Transmembrane regions
(predicted)
ARNTL2-001
ENSP00000266503
ENST00000266503
Q8WYA1 [Direct mapping]
Aryl hydrocarbon receptor nuclear translocator-like protein 2
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Kim et al 2014)
Show all
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005515 [protein binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007623 [circadian rhythm]
GO:0009649 [entrainment of circadian clock]
GO:0042753 [positive regulation of circadian rhythm]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
GO:0070888 [E-box binding]
Show all
 636 aa
70.9 kDa 		No 0
ARNTL2-002
ENSP00000442438
ENST00000544915
Q8WYA1 [Direct mapping]
Aryl hydrocarbon receptor nuclear translocator-like protein 2
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Show all
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007623 [circadian rhythm]
GO:0009649 [entrainment of circadian clock]
GO:0042753 [positive regulation of circadian rhythm]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
GO:0070888 [E-box binding]
Show all
 602 aa
67.2 kDa 		No 0
ARNTL2-003
ENSP00000438545
ENST00000546179
Q8WYA1 [Direct mapping]
Aryl hydrocarbon receptor nuclear translocator-like protein 2
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Kim et al 2014)
Show all
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007623 [circadian rhythm]
GO:0009649 [entrainment of circadian clock]
GO:0042753 [positive regulation of circadian rhythm]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
GO:0070888 [E-box binding]
Show all
 540 aa
60.4 kDa 		No 0
ARNTL2-004
ENSP00000379238
ENST00000395901
Q8WYA1 [Direct mapping]
Aryl hydrocarbon receptor nuclear translocator-like protein 2
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Kim et al 2014)
Show all
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007623 [circadian rhythm]
GO:0009649 [entrainment of circadian clock]
GO:0042753 [positive regulation of circadian rhythm]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
GO:0070888 [E-box binding]
Show all
 599 aa
66.5 kDa 		No 0
ARNTL2-005
ENSP00000312247
ENST00000311001
Q8WYA1 [Direct mapping]
Aryl hydrocarbon receptor nuclear translocator-like protein 2
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Kim et al 2014)
Show all
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007623 [circadian rhythm]
GO:0009649 [entrainment of circadian clock]
GO:0042753 [positive regulation of circadian rhythm]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
GO:0070888 [E-box binding]
Show all
 622 aa
69.2 kDa 		No 0
ARNTL2-006
ENSP00000261178
ENST00000261178
Q8WYA1 [Direct mapping]
Aryl hydrocarbon receptor nuclear translocator-like protein 2
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Protein evidence (Kim et al 2014)
Show all
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007623 [circadian rhythm]
GO:0009649 [entrainment of circadian clock]
GO:0042753 [positive regulation of circadian rhythm]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
GO:0070888 [E-box binding]
Show all
 588 aa
65.6 kDa 		No 0
ARNTL2-007
ENSP00000445836
ENST00000542388
Q8WYA1 [Direct mapping]
Aryl hydrocarbon receptor nuclear translocator-like protein 2
Show all
Predicted intracellular proteins
Transcription factors
   Basic domains
Show all
GO:0000982 [transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding]
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0005730 [nucleolus]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0006357 [regulation of transcription from RNA polymerase II promoter]
GO:0007623 [circadian rhythm]
GO:0009649 [entrainment of circadian clock]
GO:0042753 [positive regulation of circadian rhythm]
GO:0045893 [positive regulation of transcription, DNA-templated]
GO:0045944 [positive regulation of transcription from RNA polymerase II promoter]
GO:0046983 [protein dimerization activity]
GO:0070888 [E-box binding]
Show all
 551 aa
61.8 kDa 		No 0
ARNTL2-008
ENSP00000400185
ENST00000457040
H0Y5R1 [Direct mapping]
Aryl hydrocarbon receptor nuclear translocator-like protein 2
Show all
Predicted intracellular proteins
Show all
GO:0003700 [transcription factor activity, sequence-specific DNA binding]
GO:0005634 [nucleus]
GO:0005667 [transcription factor complex]
GO:0005737 [cytoplasm]
GO:0006351 [transcription, DNA-templated]
GO:0006355 [regulation of transcription, DNA-templated]
GO:0046983 [protein dimerization activity]
Show all
 588 aa
65.6 kDa 		No 0

Contact

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg foundation.