Expression of PNPLA6 in cancer - Summary - The Human Protein Atlas

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PNPLA6

TISSUE

CELL

PATHOLOGY

PATHOLOGY ATLAS

GENE/PROTEIN

Antibody validation

Dictionary


Level of antibody staining/expression
	High Medium Low Not detected

GENERAL INFORMATION
Gene name	PNPLA6
Gene description	Patatin-like phospholipase domain containing 6
Protein class	Disease related genes Enzymes Potential drug targets Predicted intracellular proteins Predicted membrane proteins
Predicted localization	Intracellular,Membrane
Number of transcripts	13
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HUMAN PROTEIN ATLAS INFORMATION

RNA category

TCGA (cancer tissue):	Expressed in all
HPA (cell line):	Expressed in all
HPA (normal tissue):	Expressed in all

Protein evidence

Evidence at protein level

Protein expression
normal tissue

General nuclear and cytoplasmic expression.

ANTIBODY IHC RELIABILITY
Data reliability description	Antibody staining mainly consistent with RNA expression data. Sub cellular location is contradicted by external data.
Reliability score	Uncertain based on 1 antibody. HPA007522
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PROGNOSTIC SUMMARY
Prognostic marker in pancreatic cancer (favourable), head and neck cancer (favourable) and renal cancer (favourable).
Pancreatic cancer p<0.001 Head and neck cancer p<0.001 Renal cancer p<0.001 Show all

RNA EXPRESSION OVERVIEW
TCGA dataset RNA cancer category: Expressed in all

PROTEIN EXPRESSION

Colorectal cancer

Prostate cancer

STAINING SUMMARY

HPA007522

GENE INFORMATION
Gene name	PNPLA6 (HGNC Symbol)
Synonyms	iPLA2delta, NTE, SPG39, sws
Description	Patatin-like phospholipase domain containing 6 (HGNC Symbol)
Entrez gene summary	This gene encodes a phospholipase that deacetylates intracellular phosphatidylcholine to produce glycerophosphocholine. It is thought to function in neurite outgrowth and process elongation during neuronal differentiation. The protein is anchored to the cytoplasmic face of the endoplasmic reticulum in both neurons and non-neuronal cells. Mutations in this gene result in autosomal recessive spastic paraplegia, and the protein is the target for neurodegeneration induced by organophosphorus compounds and chemical warfare agents. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Chromosome	19
Cytoband	p13.2
Chromosome location (bp)	7534004 - 7561764
Protein evidence	Evidence at protein level (all genes)
Ensembl	ENSG00000032444 (version 83.38)
Entrez gene	10908
UniProt	Q8IY17 (UniProt - Evidence at protein level)
neXtProt	NX_Q8IY17
Antibodypedia	PNPLA6 antibodies

PROTEIN BROWSER

PNPLA6-001	PNPLA6-002	PNPLA6-003	PNPLA6-004	PNPLA6-005	PNPLA6-008	PNPLA6-009	PNPLA6-010	PNPLA6-011	PNPLA6-012	PNPLA6-015	PNPLA6-016	PNPLA6-024

PROTEIN INFORMATION
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
PNPLA6-001 ENSP00000221249 ENST00000221249	Q8IY17 [Direct mapping] Neuropathy target esterase Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004622 [lysophospholipase activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006629 [lipid metabolic process] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016042 [lipid catabolic process] GO:0032502 [developmental process] GO:0046470 [phosphatidylcholine metabolic process] Show all	1327 aa 146.2 kDa	No	1
PNPLA6-002 ENSP00000407509 ENST00000414982	Q8IY17 [Direct mapping] Neuropathy target esterase Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0001525 [angiogenesis] GO:0004622 [lysophospholipase activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006629 [lipid metabolic process] GO:0008152 [metabolic process] GO:0009887 [organ morphogenesis] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016042 [lipid catabolic process] GO:0032502 [developmental process] GO:0046470 [phosphatidylcholine metabolic process] Show all	1375 aa 151 kDa	No	1
PNPLA6-003 ENSP00000443323 ENST00000545201	Q8IY17 [Direct mapping] Neuropathy target esterase Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004622 [lysophospholipase activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006629 [lipid metabolic process] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016042 [lipid catabolic process] GO:0032502 [developmental process] GO:0046470 [phosphatidylcholine metabolic process] Show all	1300 aa 143.4 kDa	No	1
PNPLA6-004 ENSP00000394348 ENST00000450331	Q8IY17 [Direct mapping] Neuropathy target esterase Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004622 [lysophospholipase activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006629 [lipid metabolic process] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016042 [lipid catabolic process] GO:0032502 [developmental process] GO:0046470 [phosphatidylcholine metabolic process] Show all	1327 aa 146.2 kDa	No	1
PNPLA6-005 ENSP00000470608 ENST00000601668	M0QZK5 [Direct mapping] Neuropathy target esterase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004622 [lysophospholipase activity] GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] GO:0032502 [developmental process] Show all	134 aa 14.9 kDa	No	1
PNPLA6-008 ENSP00000469794 ENST00000593924	M0QYF5 [Direct mapping] Neuropathy target esterase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004622 [lysophospholipase activity] GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] GO:0032502 [developmental process] Show all	118 aa 13.2 kDa	No	1
PNPLA6-009 ENSP00000472572 ENST00000600942	M0R2H4 [Direct mapping] Neuropathy target esterase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004622 [lysophospholipase activity] GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] GO:0032502 [developmental process] Show all	154 aa 17.3 kDa	No	1
PNPLA6-010 ENSP00000470461 ENST00000596515	M0QZD1 [Direct mapping] Neuropathy target esterase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004622 [lysophospholipase activity] GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] GO:0032502 [developmental process] Show all	38 aa 3.9 kDa	No	1
PNPLA6-011 ENSP00000472631 ENST00000601001	M0R2K2 [Direct mapping] Neuropathy target esterase Show all	Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Protein evidence (Ezkurdia et al 2014) Show all	GO:0004622 [lysophospholipase activity] GO:0005783 [endoplasmic reticulum] GO:0016021 [integral component of membrane] GO:0032502 [developmental process] Show all	181 aa 20.5 kDa	No	1
PNPLA6-012 ENSP00000473211 ENST00000600737	Q8IY17 [Direct mapping] Neuropathy target esterase Show all	Enzymes ENZYME proteins Hydrolases Predicted membrane proteins Prediction method-based Membrane proteins predicted by MDM MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins Phobius predicted membrane proteins SCAMPI predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins # TM segments-based 1TM proteins predicted by MDM Disease related genes Potential drug targets Protein evidence (Kim et al 2014) Protein evidence (Ezkurdia et al 2014) Show all	GO:0004622 [lysophospholipase activity] GO:0005783 [endoplasmic reticulum] GO:0005789 [endoplasmic reticulum membrane] GO:0006629 [lipid metabolic process] GO:0008152 [metabolic process] GO:0016020 [membrane] GO:0016021 [integral component of membrane] GO:0016042 [lipid catabolic process] GO:0032502 [developmental process] GO:0046470 [phosphatidylcholine metabolic process] Show all	1365 aa 149.9 kDa	No	1
PNPLA6-015 ENSP00000470060 ENST00000594551	M0QYT1 [Direct mapping] Neuropathy target esterase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004622 [lysophospholipase activity] GO:0005783 [endoplasmic reticulum] GO:0032502 [developmental process] Show all	192 aa 21.4 kDa	No	0
PNPLA6-016 ENSP00000472456 ENST00000595264	M0R2C2 [Direct mapping] Neuropathy target esterase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004622 [lysophospholipase activity] GO:0005783 [endoplasmic reticulum] GO:0032502 [developmental process] Show all	267 aa 29.1 kDa	No	0
PNPLA6-024 ENSP00000469171 ENST00000599947	M0QXH7 [Direct mapping] Neuropathy target esterase Show all	Predicted intracellular proteins Protein evidence (Ezkurdia et al 2014) Show all	GO:0004622 [lysophospholipase activity] GO:0005783 [endoplasmic reticulum] GO:0032502 [developmental process] Show all	155 aa 17 kDa	No	0

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